Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies. 

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.

ShapeTX is looking for a strong molecular biologist and virologist to join the Delivery Sciences team as a Scientist / Sr. Scientist, Viral Vector Engineering and Production. In this position, the successful candidate will build a viral production core that supports the broader Research team, as well as contribute to the design of ShapeTX’s viral vector platforms. The ideal candidate will have broad expertise with AAV and LV production, as well as experience designing and generating viral vectors to deliver genetic payloads. Strong organizational skills, the ability to tackle multiple projects simultaneously and a desire to work in a fast-paced startup environment are essential.

Roles and Responsibilities

  • Establish a viral production core to support the Research team
  • Develop standardized AAV and LV production and purification protocols and QC assays
  • Design and implement a virus request and tracking system
  • Hire and manage individuals to build the viral production core and support Research requests
  • Perform a broad range of molecular biology techniques (e.g. DNA isolation from cells/tissues, RNA isolation, cDNA generation, Sanger sequencing, next-generation sequencing, qPCR, ddPCR, etc.)
  • Collaborate with the CMC Process and Product Development team to share best practices and align viral production and analytical techniques
  • Contribute to viral vector design to package novel ShapeTX payload technologies
  • Maintain a detailed electronic laboratory notebook

Requirements:

Qualifications:

  • PhD in molecular biology, virology or related discipline
  • 3+ years of post-degree experience in an academic or industry laboratory setting

Skills and Experience:

  • AAV and LV virus production and purification, including protocol development
  • Restriction enzyme cloning, Gibson Assembly, Golden Gate Assembly
  • qPCR/ddPCR principles and analysis
  • DNA/RNA sequencing and analysis
  • Protein purification using the AKTA/Unicorn software
  • Mammalian cell culture and good aseptic technique
  • Ability to troubleshoot and think analytically
  • Strong work ethic and a collaborative, team player
  • Strong attention to detail
  • Ability to multitask and support multiple projects simultaneously
  • Effective communication 

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