Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies. 

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.


ShapeTX is looking for a gene therapy industry leader with AAV expertise to serve as Head of Delivery Sciences. In this role, you will refine and execute the company’s viral and nonviral delivery strategy, manage a growing team of high performing scientists and engage with internal and external stakeholders to advance ShapeTX’s delivery platform. This role will be Research-focused, but you will collaborate closely with the CMC team to guide the transition of therapeutic candidates from Research into Manufacturing. You will serve on the Research Leadership Team and play a key role in aligning Delivery Sciences with Technology Development and Disease Biology. You will also be expected to exemplify and cultivate ShapeTX’s values and culture.

This is an exciting opportunity to join a high-growth startup and lead the delivery strategy for a pioneering RNA targeting technology to create the next generation of gene therapies. The ideal candidate will have deep expertise in AAV engineering and application to gene therapy, with a demonstrated track record of successful research-to-development transitions. Creativity, scientific rigor and a thirst for excellence are essential.

Title and compensation commensurate with level of experience.

Roles and Responsibilities

  • Oversee the development of ShapeTx’s Delivery Sciences Team, encompassing AAV capsid engineering, AAV vector optimization and AAV production, as well as select non-viral technologies
  • Refine and execute a strategy for Delivery Sciences that is aligned with company leadership and collaborative partners, encompassing virus engineering, vector optimization, screening, analytics, and research-scale manufacturing.
  • Provide technical and managerial leadership to team members (e.g. day-to-day technical guidance, data review, project and people management, etc.)
  • Apply a data-driven strategic framework to prioritize resource allocation and make effective “go/no-go” decisions
  • Evaluate new delivery technology opportunities, both viral and non-viral, in collaboration with Business Development and the Research Leadership Team
  • Engage with Process Development/CMC, Regulatory and Nonclinical Development to support the Research-to-Development transition of therapeutic candidates
  • Manage career development and performance of research staff, hire top talent and integrate new team members to maintain a strong team dynamic of respect, creativity and collaboration
  • Oversee competitive intelligence in relevant scientific areas by interacting with external experts, attending scientific meetings, and staying up-to-date on literature
  • Represent ShapeTx to the external scientific community via presentations, publications, etc.
  • Contribute to the patent landscape to ensure unique IP creation and subsequent filing of patents

 

Requirements:

Preferred Qualifications:

  • PhD in virology, molecular biology or related life science discipline
  • At least 10 years of experience in the biotechnology and/or pharmaceutical industry
  • At least 5 years of technical leadership and proven ability to manage high performing teams effectively
  • Expertise in AAV biology, therapeutic vector delivery and a demonstrated ability of taking a viral vector-based product into clinical development
  • Proven success and strong track record in gene therapy and delivery methods through publications in top tier journals and asset creation

Skills and Experience:

  • Ability to operate and thrive in a fast-paced, start-up environment
  • Entrepreneurial mindset and ability to function in a complex and ambiguous environment
  • Ability to lead, mentor and develop scientific talent at different levels
  • Excellent communication and decision-making skills
  • Ability to dive into technical details and discussions on active research programs 
  • Skilled in business relationship management with internal and external partners

Apply for this Job

* Required

  
  


U.S. Equal Opportunity Employment Information (Completion is voluntary)

Individuals seeking employment at Shape Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information in order to help us comply with federal and state Equal Employment Opportunity/Affirmative Action record keeping, reporting, and other legal requirements.

Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.


Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.