Shape Therapeutics (ShapeTx) is a development stage biotechnology company establishing itself as the leader in next generation gene therapy. Our novel technology platform enables direct in vivo targeting of RNA by leveraging ADARs (Adenosine Deaminase Acting on RNA), suppressor tRNAs, and the capability to redose with adeno-associated viruses (AAVs).
ShapeTx is providing solutions to many of the challenges that contemporary genome engineering technologies face (like CRISPR, TALENs, etc.), such as permanent off-target damage, high risk of immunogenicity and therefore low in vivo applicability as effective gene therapy approaches. ShapeTx’s technology instead engages natural human cellular machinery to target RNA with high in vivo efficiency.
At ShapeTx, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases.
Shape Therapeutics is headquartered in Seattle, Washington with satellite sites in Cambridge, Massachusetts and San Francisco, California.
ShapeTx is looking for a highly motivated individual with a strong passion for learning to join the Research team as Research Associate, Neurobiology. In this role, the successful candidate will work with neurobiology project leads to conduct in vitro and in vivo experiments to enable efficient project advancement. An ideal candidate will have broad neurobiology or cell biology experience, a collaborative spirit and a desire to work in a fast-paced startup environment.
Roles and Responsibilities
Independently follow established protocols, analyze and communicate results
Assist in cell line maintenance, generation and tissue culture
Assist in animal maintenance, blood collection, injections, tissue harvests
Perform a broad range of molecular and cell biology techniques (e.g. DNA isolation, RNA isolation, cDNA generation, qPCR, ddPCR, immunoblotting, immunofluorescence, imaging etc.)
Maintain a detailed electronic laboratory notebook
Assist in lab organization and supply ordering
Bachelor of Science degree in Neuroscience, Cell Biology, or related discipline
2+ years of experience in an academic or industry laboratory setting
Skills and Experience:
Mammalian cell culture and good aseptic technique
Rodent handling and a desire to learn more complex skills
qPCR/ddPCR principles and analysis
Ability to troubleshoot and think analytically
Strong work ethic
A collaborative, team player
Attention to detail
Ability to multitask and support multiple projects simultaneously