Shape Therapeutics (ShapeTx) is a development-stage biotechnology company establishing itself as the leader in next-generation gene therapy. Our novel technology platform enables direct in vivo targeting/modification of RNA by leveraging ADARs (Adenosine Deaminase Acting on RNA), suppressor tRNAs, and immune-stealth adeno-associated viruses (AAVs).
ShapeTx is providing solutions to many of the challenges that contemporary genome engineering technologies face (like CRISPR, TALENs, etc.), such as permanent off-target damage, high risk of immunogenicity and therefore low in vivo applicability as effective gene therapy approaches. ShapeTx’s technology instead engages natural human cellular machinery to target RNA with high in vivo efficiency.
At ShapeTx, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases.
Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.
ShapeTx is looking for a scientifically innovative individual to join the Research team as Scientist/Sr. Scientist, Molecular Biology. In this position, the successful candidate will advance technology development across ShapeTx's novel gene therapy platforms by adopting cutting-edge methods to create higher-throughput, lower-volume, multiplexed and automated assays. This role will contribute to multiple areas within the company, from basic research to preclinical development to manufacturing. The ideal candidate will have a strong problem-solving attitude, intellectual motivation to adopt new technologies and appetite for high-risk/high-reward projects. Creativity, scientific rigor and a thirst for excellence are essential.
Roles and Responsibilities:
- Optimize ShapeTx’s RNA-targeting platform and develop high-throughput assays to quantify on- and off-target RNA editing and knockdown
- Partner with disease biology teams to design new screening tools and analyze treatment phenotypes that enable lead candidate selection for therapeutic applications
- Assist the manufacturing teams to implement advanced protocols to measure viral yield and purity
- Design, execute, and evaluate experiments – both independently and with others
- Participate in and present project results during research meetings
- Keep organized and detailed records using an electronic laboratory notebook
- PhD in molecular biology, bioengineering, or a related life science discipline
- 1-5 years of post-doctoral research and/or biotech industry experience
- Demonstrated track record of technology development through high profile peer-reviewed publications and patents
Skills and Experience:
- Mastery of various nucleic acid purification, quantitation, and sequencing methods
- Direct experience in innovating protocols and using technology to improve assays
- Broad experience using current molecular biology, cell biology, synthetic biology and gene editing techniques (e.g. qPCR, ddPCR, RNASeq, gene synthesis, Crispr)
- Experience with library preparation and next-generation sequencing
- Experience with mammalian cell culture, cell and tissue analysis methods
- Ability to thrive in a fast-paced start up environment
- Ability to work both independently and collaboratively in a team-science environment across multiple locations
- Ability to think outside the box and tackle challenges with a problem-solving attitude
- Excellent written and oral communication skills