Shape Therapeutics (ShapeTx) is a development stage biotechnology company establishing itself as the leader in next generation gene therapy. Our novel technology platform enables direct in vivo targeting of RNA by leveraging ADARs (Adenosine Deaminase Acting on RNA), suppressor tRNAs, and the capability to redose with adeno-associated viruses (AAVs).
ShapeTx is providing solutions to many of the challenges that contemporary genome engineering technologies face (like CRISPR, TALENs, etc.), such as permanent off-target damage, high risk of immunogenicity and therefore low in vivo applicability as effective gene therapy approaches. ShapeTx’s technology instead engages natural human cellular machinery to target RNA with high in vivo efficiency.
At ShapeTx, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases.
Shape Therapeutics is headquartered in Seattle, Washington with satellite sites in San Diego and San Francisco, California.
The Research Team is looking for an experienced and motivated individual for the role of Sr. Scientist/ Scientist, RNA Biology. In this position, you will be instrumental in developing cutting-edge RNA editing protocols and constructs. You will have a pioneering role in the burgeoning new field of RNA editing.
Roles and Responsibilities:
Design and evaluate novel guide RNA architectures
Develop high-throughput assays to quantify on- and off-target RNA editing and knockdown
Determine sequence preferences for the RNAfix platform
Screen and optimize lead candidate constructs for IND enabling studies
Investigate RNA targeting strategies to apply RNAfix for disease programs
Design, execute, and evaluate experiments – both independently and with others
Participate and present project results during research meetings
Keep organized and detailed records using an electronic laboratory notebook
PhD in Molecular Biology or a related life science discipline
Expertise in RNA editing, alternative splicing, pre-mRNA, tRNA, lncRNA, RNA secondary structure, or RNA-binding protein structures (ribosomes, spliceosomes, etc.)
Skills and Experience:
Mastery of RNA isolation, quantitation (qPCR, ddPCR)
RNASeq library preparation and computational analysis methods
Enthusiasm and knowledge of latest reagents and technologies, especially in synthetic biology, multiplexing, and automation
Mammalian tissue culture experience preferred
Ability to work independently and collaboratively in a team-science environment
Ability to think outside the box and tackle challenges with a problem-solving attitude