About Senda Biosciences

Senda Biosciences, Inc. is uniquely positioned to transform human health by harnessing millions of years of evolution to program targeted, potent and tunable medicines. Nature has provided the codes to program human cells – both from within (mRNA) and from outside – from what surrounds them. The trillions of non-human cells in the human ecosystem have evolved natural nanoparticles that precisely shuttle biomolecules into human cells, providing the missing pieces to fully unlock programmable medicines. Senda’s proprietary platform includes the first-ever atlas of nature-derived programmable systems at the molecular level and across all kingdoms of life – accessing the entire code provided by nature required to program cells.  With this platform, Senda is developing a new class of SendRNA™ medicines.  The unique properties of these medicines create new frontiers for mRNA therapeutics and vaccines for infectious, genetic, autoimmune, and metabolic diseases and oncology indications – with further potential to transform the gene editing and protein-based therapy landscapes as well.  Based in Cambridge, MA, Senda was founded by Flagship Pioneering. For more information, visit sendabiosciences.com or follow us on Twitter and LinkedIn.

The Position:

We are seeking to hire an innovative and highly motivated Associate Director to join the Translational Biology group at Senda Biosciences in developing a transformative platform for Senda’s programmable medicines. As a critical cross functional member of Senda Biosciences research team, the Associate Director will take lead, advance the development and execution of strategies to drive forward the development of Senda’s SendRNA programmable medicines towards IND. You can expect to engage deeply in interdisciplinary research, working as part of a cross-disciplinary team of immunologist, formulation scientist, engineers, and data scientists. This individual will be a key member of Senda Biosciences’s dynamic, expanding, and collaborative team that combines significant experience in immunology, in vivo biology, cell trafficking and targeting and immuno-oncology to unlock the potential of the company’s core technological platforms. We are looking for an Associate Director with experience in forward and reverse translational approaches to advance and expand Senda’s portfolio. Applicants ideally will have experience in multiple arms of immunology, a good understanding of in vivo models and diverse biology background. The successful candidate is both an outstanding scientist and effective collaborator, and thrives in a fast-paced, results-oriented environment managing several projects in parallel and have experience managing teams of scientists. They will work as part of a cross-functional team of immunologist, in vivo biologist, analytical and formulation scientists, and computational biologists to establish the foundational data sets to build Senda’s pipeline and develop novel medicine for patients.

Responsibilities:

  • Conceive and establish immunological assays to support Senda’s platform and program development pipeline.
  • Identify, design experiments and establish novel targets and disease models align with Senda’s pipeline
  • Manage internal/external research teams in data generation and analysis while instituting rigorous standards.
  • Develop and support the routine performance of a variety of immunological assays, cell-based assays, microscopy and imaging, co-cultures and ex vivo assays as well as flow cytometry panel design and execution.
  • Work closely with CROs to develop assays and immunological endpoint evaluations for supporting several groups at Senda.   
  • Lead technical transfer of immunological in vivo assays to CROs and support life-cycle management of these outsourced assays
  • Work closely with cross-functional teams across the Senda, collaborators and CROs to progress candidates from discovery through IND-enabling studies.
  • Develop and implement a variety of functional assays to support immune-oncology effort, in vivo immune cell targeting and various delivery modalities.
  • Identify and implement relevant novel immunological approaches and technology to accelerate infectious disease and immune-oncology research
  • Manage multiple experiments, projects, and interactions with supporting functions simultaneously
  • Interpret, troubleshoot, and report complex data
  • Build and manage an in vivo and ex vivo scientist team.
  • Maintain expertise in the field of immunology, trafficking, immune-oncology, LNP delivery systems, RNA biology, through keeping abreast of literature, attending relevant meetings, and liaison with external experts in the field.
  • Manage multiple projects and interaction with supporting functions.
  • Provide scientific and technical support for multidisciplinary project teams.
  • Prepare documents and present strategy, results, project updates, and summaries.

Here’s What You’ll Bring to the Table:

  • D. in Biology, Microbiology or Immunology with at least 3 years of related postdoctoral research experience and minimum 3 years in biotech industry or minimum 5 years in biotech industry.
  • Knowledge and experience in vaccine, immune-oncology and immune cell targeting. 
  • Experience in CRO management and academic collaborations
  • Deep understanding of Infectious disease pathogenesis, cell trafficking, in vivo systems and immunology
  • Expertise in the design and set up of a variety of serological assays, cell-based assays, and functional assays. 
  • Experience managing researchers in a dynamic environment.
  • Excellent written, presentation and interpersonal communication skills; ability to influence and collaborate in a team environment.
  • Expertise in execution of assays and clear communication of data is required
  • Proven track record of high impact publications and presentations in the field of infectious diseases, immunology or immune-oncology.
  • The ability to work in a cross-functional work environment is critical; strong leadership skills and independence skills are expected.
  • Excellent team spirit, communication, and presentation skills
  • Candidate will be curious in exploring new avenues for evaluating anti-tumor responses, mechanism of action, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
  • Preferred: 3 years of postdoctoral experience + 3 years of biotech industry or minimum 5 years of independent research experience in the pharmaceutical or biotech industry

 

Senda Biosciences is an Equal Opportunity Employer. Senda does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

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