About Scribe:

Scribe uses holistic molecular engineering to design, evolve, build and apply exclusive CRISPR technologies with enhanced therapeutic attributes for in vivo use. The company’s first technology, X-Editing (XE) molecules, are highly engineered CRISPR enzymes that provide combined aspects of greater efficacy, specificity and deliverability than currently available CRISPR genome editing technology. While Scribe’s engineering core continues to evolve and expand, the company is simultaneously addressing diseases of significant unmet need.

Scribe Therapeutics is seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of therapeutic molecules. The current role is for a Scientist with deep expertise in virology, vectorology, molecular biology, and mammalian cell biology who will join our platform engineering team. The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals. 

Key Responsibilities:

  • Work closely with a core engineering team to creatively design, rapidly build, and efficiently screen AAV vectors for the optimal delivery of genome editing tools to CNS tissues.
  • Design and execute hypothesis-driven and properly controlled studies, analyze data with rigorous statistics, and write up publication quality reports. 
  • Assume project responsibilities and effectively present updates, and communicate research plans and timelines to the senior leadership team.
  • Effectively collaborate with members within a fully integrated team to facilitate execution on projects within established timelines.
  • Seamlessly interface and coordinate with other teams at Scribe to accomplish common goals.
  • Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science

Required Skills and Background:

  • A PhD in Virology, Cell or Molecular Biology, Neuroscience or related discipline. 1+ years experience in a post-doctorate or in the pharmaceutical industry is a plus.
  • Experience in designing and implementing AAV vectors for delivery to the CNS.
  • Deep knowledge of all aspects of AAV biology 
  • Experience with CRISPR-Cas gene editing system, preferably in the context of delivery by AAV vectors to the CNS.
  • Advanced expertise in the latest molecular and cellular biology techniques.
  • Expertise in use of mammalian cell reporter systems, screening in human cells, and readout by FACS and NGS analysis. 
  • Expertise in molecular biology, RNA and protein analysis (e.g. qPCR, RT-qPCR, Western, etc.) 
  • Demonstrated scientific productivity and drive as evidenced by a strong publication record in top tier journals.
  • Ability to work collaboratively in a fast-paced, interdisciplinary research team.
  • Excellent prioritization and organization skills.

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Please contact us and include your CV or résumé. 

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

Scribe Therapeutics is a molecular engineering company focused on building best-in-class in vivo therapies to permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen platform for CRISPR-based genetic medicine. We are a dynamic team of energetic, creative, world-class experts who are looking for like-minded passionate colleagues to enable the future of genetic medicine. The company is backed by leading individual and institutional investors including Andreessen Horowitz. To learn more about Scribe’s mission to rewrite the story of disease, visit www.scribetx.com.

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

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