Scorpion is a pioneering clinical-stage oncology company redefining the frontier of precision medicine to deliver optimized and transformational therapies for larger populations of patients with cancer. Scorpion has built a proprietary and fully integrated platform of the most advanced technologies across cancer biology, medicinal chemistry, and data sciences, with the goal of consistently and rapidly creating exquisitely selective small molecule compounds against an unprecedented spectrum of targets. Scorpion aims to leverage its platform to advance a broad pipeline of wholly owned, optimized compounds across three target categories: best-in-class molecules targeting validated oncogene targets; first-in-class molecules for previously undruggable targets; and first-in-class molecules for novel cancer targets.

Job Description

The position is responsible for technical leadership of analytical development within the CMC function across Scorpion’s portfolio.  Analytical Development has responsibility for analytical activities from late-stage Discovery (lead optimization, development candidate nomination) through early-stage clinical development for small molecule programs. The candidate will ensure success on all drug substance and drug product deliverables by leveraging internal and external resources. They will also be responsible for strategic and scientific alignment of analytical development activities with the overall program needs.

The candidate should have a proven track record of leadership, mentorship, and technical achievement working within a cross-functional matrix environment.  They should be a leader in the scientific community, capable of effectively managing technical issues with their function and providing expertise throughout the company.  This individual should actively maintain and champion state-of-the-art scientific and technical knowledge, implementing creative ways to solve challenging problems for new and ongoing projects.

Qualifications

  • PhD in chemistry, chemical technologies or related area with 15+ years relevant experience in analytical development roles within the pharmaceutical industry
  • Expertise in phase-appropriate small molecule analytical method development and validation
  • Extensive knowledge of advanced analytical principles and theories; expertise in analytical laboratory techniques for drug substance and drug product and application of control strategies through all stages of development
  • Knowledge and experience of pre-development activities – pre-formulation, solid state, formulations for animal studies
  • Demonstrated ability to set clear and measurable goals, managing tasks and resources
  • Excellent written and verbal communication skills, organization, and planning skills and a high level of technical aptitude and creativity
  • Expertise in all relevant Quality and Regulatory guidelines with the ability to provide mentorship, oversight and review of all relevant Analytical Development source documents for regulatory submission
  • Ability to implement new technologies for development programs
  • Ability to develop and maintain project plans for internal and external analytical resources, timelines, and budgets
  • Proven track record of building strong collaborations and relationships with external CDMOs, internal technical leads and project teams

 

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

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