Your work will change lives. Including your own. 

Building a map of human biology is uncharted territory. Come help us pave the way.

Nine years ago, we were staining plates by hand. Today, we've created a library of more than one billion cellular images on the basis of a radically different approach to biotech. This is a bold approach that we believe will reinvent drug discovery and development. 

If you draw a line from nine years ago to today, you’ll see our trajectory and understand that Recursion is a very different kind of company. You cannot make these kinds of leaps simply by adding incubators, fluorescent microscopes, and robots to automate processes at scale. Our drug discovery strategies are map and data-driven rather than target-driven, revealing destinations you might never have considered. As a Principal Scientist at Recursion, you’ll be in a position to directly accelerate the timeline of getting drugs into the hands of patients who need them.

The Impact You’ll Make

You will engage in early drug discovery projects from launch to preclinical development and help our efforts in advancing new therapeutics to patients. You will be at the forefront of developing new approaches that reimagine small molecule drug discovery leveraging Recursion’s extensive data capabilities. As a Principal Scientist, you will:

  • Build - In partnership with medicinal chemists, biologists, data scientists, and others, you will build projects across therapeutic models designed to translate phenotypic screening hits to preclinical assets with quality and speed
  • Lead - You will lead cross-functional computational and medicinal chemistry efforts, as part of a nimble, highly efficient chemistry team
  • Collaborate - Work in a cross-functional matrix organization with biologists, chemists, data scientists, and engineers with a passion for drug discovery
  • Communicate - Independently prepare impactful presentations for senior leaders and partners to allow for informed data-based decision-making
  • Achieve - Understand the critical path and provide high-quality results

The Team You’ll Join 

Reporting to our Director of Applied Chemistry, you will be a leader within our discovery organization, partnering with others to build and advance the portfolio of preclinical small molecule NCE and repurposed assets. You will use your depth and breadth of understanding of computational and medicinal chemistry to lead molecular modeling efforts that inform programs and find synergistic opportunities to capitalize on Recursion’s AI-enabled high throughput phenotypic screening platform. You will work in a highly matrixed organization to advance molecules from hit identification to lead series and ultimately to candidate status. Your skills will be of high value as you work cross-functionally internally, with external stakeholders and contract chemistry FTEs.

The Experience You’ll Need

  • Ph.D. in computational chemistry, biophysics, medicinal chemistry, engineering, or equivalent
  • 5+ years as a computational chemistry program lead in drug discovery/development within a  biotech or pharma setting
  • Strong record of delivery as demonstrated by publications, presentations, patents, or other evidence of creative application of computational approaches to problems of pharmaceutical interest
  • Proficiency in general molecular modeling techniques (docking, molecular simulation, homology modeling, quantum mechanics, pharmacophore and shape screening, ligand- and structure-based design)
  • Experience providing project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints
  • Experience in contributing to the identification, development, validation, and implementation of innovative computational approaches that improve research productivity and success

Preferred Experience and Skills:

  • Experience with Linux and HPC environments.
  • Proficiency with modeling software packages (e.g. Maestro, LiveDesign, MOE, OpenEye, Rosetta, etc.).
  • Proficiency in scientific scripting and programming languages (e.g. Bash, Python).


The Values That We Hope You Share:

  • We Care: We care about our drug candidates, our Recursionauts, their families, each other, our communities, the patients we aim to serve and their loved ones. We also care about our work.
  • We Learn: Learning from the diverse perspectives of our fellow Recursionauts, and from failure, is an essential part of how we make progress.
  • We Deliver: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: we sprint at maximum engagement, making time and space to recover. 
  • Act Boldly with Integrity: No company changes the world or reinvents an industry without being bold. It must be balanced; not by timidity, but by doing the right thing even when no one is looking.
  • We are One Recursion: We operate with a 'company first, team second' mentality. Our success comes from working as one interdisciplinary team.

Recursion spends time and energy connecting every aspect of work to these values. They aren’t static, but regularly discussed and questioned because we make decisions rooted in those values in our day-to-day work. You can read more about our values and how we live them every day here.

More About Recursion 

Central to our mission is the Recursion Operating System, or Recursion OS, that combines an advanced infrastructure layer to generate what we believe is one of the world’s largest and fastest-growing proprietary biological and chemical datasets and the Recursion Map, a suite of custom software, algorithms, and machine learning tools that we use to explore foundational biology unconstrained by human bias and navigate to new biological insights which may accelerate our programs. We are a biotechnology company scaling more like a technology company. Recursion is proudly headquartered in Salt Lake City. 

Learn more at, or connect on Twitter and LinkedIn.

Recursion is an Equal Opportunity Employer that values diversity and inclusion.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation. 

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)

Equal Opportunity Employment Information (Completion is Voluntary)

Recursion is a proud equal opportunity employer. 

We have a fundamental belief that we can only achieve our mission if we truly commit to diversity, equity and inclusion. We believe diversity makes us stronger, and it's our responsibility to build an equitable and inclusive workplace where our diverse talent thrives.  To this end, we invite you to self-identify your race/ethnicity and gender. This information will be kept confidential and will not be shared with the hiring managers or otherwise considered as part of your application. Submission of this information is voluntary and refusal to provide any or all of the information requested will not subject you to any adverse treatment.  If you are willing, please let us know if you identify as belonging to any of the following groups:

Race/Ethnicity (please select one) *

Gender Identity (please select one) *