Who We Are:

ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode’s proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency. ReCode’s lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators. RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.

Summary of Position:

We are seeking a highly motivated and scientifically rigorous individual to join the Formulation team. The position will focus on the development and application of experimental techniques to characterize and optimize delivery of novel LNP-formulations with diverse RNA cargos. In this role you will work with cross-functional product development team including process development and analytical development to develop formulations with a good safety profile and high potency in vitro and in vivo.  

Job Responsibilities

  • Design experiments to conduct rationale LNP formulation design and optimization to support preclinical discovery formulation and clinical candidate formulation development efforts.
  • Evaluate the effect of each formulation component on potency, safety, and stability.
  • Provide formulations expertise and insights to various interdisciplinary teams.
  • Perform formulation transfer to process development teams and provide troubleshooting when needed.
  • Execute rational formulation selection and characterization studies relevant to the stage of development.  Studies include, but are not limited to, composition screening, stability, biophysical characterization, etc.
  • Collaborate with other functions to develop and execute analytical methods to characterize formulations with diverse and mixed nucleic acid cargos.
  • Rational experimental planning and protocol writing. Collect data in (electronic) laboratory notebooks and provide data summaries.
  • Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams.
  • Communicate regularly with team members regarding project progress.
  • Help mentoring junior team members.
  • Contribute to lab management activities.

Required Skills & Qualifications

  • MS in chemistry, bioengineering, chemical engineering, or a related discipline with 6+ years of direct relevant industry experience desired.
  • PhD in chemistry, bioengineering, chemical engineering, or a related discipline. Comparatively, a candidate PhD in chemistry, bioengineering, chemical engineering, or a related discipline with 1-2 years industry experience.
  • A strong background in non-viral delivery platforms is preferred.
  • Hands-on experimental skills (e.g., experience in formulation and formulation characterization) with 3-6 years of relevant experience in drug delivery research.
  • Prior experience working with lipid nano particle delivery systems is strongly desired.
  • Proficiency in analytical techniques (HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry).
  • Direct experience with RNA product characterization/handling is preferred.
  • Thorough understanding of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is desirable.
  • Ability to maintain accurate and well-organized laboratory records.
  • Excellent organizational and oral/written communication skills.
  • Rigorous analytical, troubleshooting, and problem-solving skills.
  • Works independently as well as collaboratively within groups and interdisciplinary teams.
  • Desire to work in a fast-paced environment.

Salary Range: *90,000 - 110,000

*Please note that for remote positions, salary may be adjusted for cost of living

Benefits Offered for Full-Time Employees: 

  • No premium cost for employees - 100% subsidized by ReCode for full-time employees
  • Company 401k contribution
  • 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
  • Mental health support for employees & their families
  • FSA available, including a lifestyle spending account subsidized by company
  • Employee discounts at hotspots

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.

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