Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Berkeley, CA, we are backed by leading investors including Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures.

Profluent is currently seeking a creative, passionate, and detail-oriented individual to join our Platform Discovery team. The candidate will help develop and execute our high-throughput screening platforms aimed at building high quality gene editing data sets for our AI-based protein engineering models. This individual will be critical in Profluent’s quest to develop powerful and novel gene editing technology to address major unmet needs in therapeutics and beyond.  

This is an excellent opportunity to shape the future of AI-driven protein design, and to work cross-functionally with a diverse team of experts across machine learning, protein engineering, cell biology, and gene editing.   


  • Design and execute high throughput molecular cloning strategies
  • Contribute to the ideation, development, automation, and execution of robust platforms for the discovery and characterization of novel gene editing tools
  • Develop and validate assays to measure on- and off-target activity of novel gene editing systems using a combination of targeted and genome-wide analytical methods
  • NGS library preparation, purification, quantitation, and final quality evaluation
  • Analyze data, interpret results, present findings to team members


  • BS or MS in molecular biology, genome sciences, biochemistry, or a related field
  • 0-5 years of academic or biotechnology industry research experience
  • Extensive, hands-on experience with molecular cloning and/or mammalian cell culture

Preferences (but not required)

  • Experience with CRISPR and/or mammalian cell-based gene editing workflows
  • Experience with medium-to-high throughput screening workflows in mammalian cells
  • Experience with protein engineering and/or structure-function studies
  • Experience with process automation and scaling to develop high throughput workflows

Actual salary will be determined based on relevant skills, qualifications, experience, training, and market data. Benefits package may vary depending on company policies and eligibility criteria.

Salary Range
$79,000$116,000 USD

What we offer at Profluent

  • A high-growth opportunity with meaningful impact
  • Competitive compensation package
  • Health insurance (health/dental/vision)
  • Generous paid time off (PTO) policy
  • Commitment to physical and mental well-being
  • More benefits and perks to be added!

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

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