Personalis is a rapidly growing cancer genomics company transforming the development of next-generation therapies by providing more comprehensive molecular data about each patient’s cancer and immune response. Our ImmunoID NeXT Platform® is enabling the development of next generation immuno-oncology therapeutics and diagnostics.


The ideal candidate will have working knowledge of U.S. GAAP and outstanding problem solving and interpersonal skills to be highly effective, and also, enjoy working in a fast-paced environment. This is a hands-on position requires a deep and broad knowledge of accounting and finance in order to create policies and procedures that keep pace with the growth of the company. This position reports to Associate Director, Accounting and will be located at our headquarters in Menlo Park, CA. This is a regular, full-time, exempt position.

The Senior Accounting Manager is expected to lead and manage general ledger functions and processes, accounts receivable, accounts payable, payroll, cash management, fixed assets, and adhere to the company’s internal controls. 


  • Manage the U.S. accounting functions that include general ledger, accounts payable and employee expense reports, customer invoicing and accounts receivable, payroll and payroll tax filings, and sales commissions.  
  • Supervise staff and provide development and coaching where appropriate.
  • Lead month end and quarterly end close process for US accounting operations
  • Ensure all journal entries and account reconciliations on US book are completed accurately and on time as reviewer.
  • Prepare and review flux analysis for balance sheets acct and expense by cost center line items drill down and explain the key drivers of the changes.
  • Responsible for quarterly audit schedules and PBC requests.
  • Review customer invoicing and revenue accounting, as well as overseeing sales administration functions, including weekly reporting. 
  • Able to effectively communicate and follow-up to ensure accurate and timely execution of key deliverables by all team members.
  • Own SOX controls for monthly, quarterly and annual close process and support relevant testing by internal and external auditors.
  • Support and drive finance transformation projects and act as change agent.
  • Other duties as assigned.


  • 7 to 10 years of growing responsibility experience in accounting / finance, including public company, CPA preferred
  • Bachelor’s degree in accounting/related field 
  • Proficiency in Excel, Word and PowerPoint. Familiarity QAD or other ERP applications such as Oracle, SAP, or Netsuite 
  • Self-starter with strong communication and organizational skills who pays attention to details.
  • Ability to work with a high degree of accuracy, detailed oriented and meet tight deadlines.
  • Team player with “can do” attitude
  • Excellent analytical abilities

Key Competencies:

  • Strong US GAAP working knowledge
  • Strong analytical and problem-solving skills.
  • Strong Excel and data analytics skills.
  • Exceptional organizational, multi-tasking, anticipatory and follow up skills.
  • Team player that works well with employees both above and below this position.
  • Excellent oral and written communication skills and demonstrated ability to communicate at all levels of the organization.

Key Behaviors:

  • Well organized.
  • Good time management skills.
  • Self-starter with the ability to work with, manage and prioritize multiple deadlines.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities.  Personalis offers a competitive compensation package. 

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