PatientsLikeMe has over a decade of experience operating a unique platform where patients with over 2500+ conditions can come together and share data: clinical data (e.g., what treatments they are taking or what their diagnoses are), experiential data (e.g., how do you rate how you feel today?), and patient reported outcomes (e.g., the ALSFRS, which is a functional rating scale that ALS patients can take in order to track their disease progression). These data can help individuals track the details of their condition such that they can observe patterns and make improvements. 

Now, PatientsLikeMe has embarked upon DigitalMe, a program whereby we are not only capturing the data types outlined above, but also longitudinal blood samples from our patients that wish to participate. On these samples, we will have the ability to run a full omics panel: DNAseq, RNAseq, methylomics, proteomics, antibody immunosignatures, immunosequencing, metabolomics for now but we are continually evaluating the newest technologies in high-throughput biological measurements. For each patient sample, we can have millions of biological measurements, plus all of patient-generated health data, in order to do our research. The remit for our team is that we make sense of all of this, in order to help patients understand their own biology, how that biology relates to their experience and their clinical data, and how they can make modulations to their daily life to optimally thrive. 

As Senior Scientist for Computational Biology, you will work within a creative team of dedicated scientists to build a technology stack capable of storing, processing and analyzing multi-omic measurements taken from longitudinal biosamples from thousands of individuals. You will participate in evaluating the strengths and weaknesses of multiple ‘omics platforms, and building the data analysis pipelines for those platforms in a scalable fashion. You will also aid in the development of creative and novel methodologies to integrate different kinds of high-throughput data modalities, together with clinical measures and patient reported outcomes into biological models for individual patients and groups of patients. You will build and analyze large-scale patient data sets. You must work closely with the systems biologists that will be evaluating the outcomes of your computational analyses in order to deliver tools for biological discovery.

You will also be responsible for working with the biological knowledge management team and engineers to implement the necessary infrastructure to support data storage, architecture, knowledge management, and tool development. This will include evaluating the technologies of our partners and making strategic decisions about how to either integrate this code base or develop new code base to support future operations. When necessary, you may be called upon to support scientific consulting engagements, and you will be expected to contribute to publications in peer-reviewed journals with significant impact. You will be responsible for supporting the development of strategic plans for the development and evolution of the technology stack. We are particularly interested in candidates that have experience with mass spectrometry.

Title is commensurate with experience. The ideal candidate possess a significant number of the qualifications/capabilities listed below:

  • D in Computational Biology, Bioengineering, Bioinformatics, Statistics, Biostatistics, Data Science or a related discipline (or a B.S/M.S. with commensurate experience), plus at least 1-5 years of experience in industry
  • Ability to communicate complex computational biology concepts to biologists and lay persons
  • Freshman college level understanding of molecular biology.
  • Ability thrive in a fast-paced, demanding, and growing environment
  • Proven track record in establishing data analysis pipelines and building tools for other computational biologists and computationally savvy biologists
  • Expertise in complex analytical techniques for omics data. Experience with integrating multi-omics data is a plus
  • Solid working knowledge of machine-learning approaches and applications to patient data
  • Ability to collaborate with AI and data science experts
  • Desire to solve extremely complex problems with scientific rigor, integrity and systematic attention to detail
  • Outstanding team player and collaborator. Ability to work independently to deadlines
  • Experience with mass spectrometry, particularly for metabolomics, proteomics, or lipidomics is a plus
  • Must be local to our Cambridge office, or willing to relocate
Apply for this Job
* Required
Almost there! Review your information then click 'Submit Application' to apply.

File   X
File   X

U.S. Equal Opportunity Employment Information (Completion is voluntary)

Individuals seeking employment at PatientsLikeMe are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information in order to help us comply with federal and state Equal Employment Opportunity/Affirmative Action record keeping, reporting, and other legal requirements.

Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 1/31/2020

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

Because we do business with the government, we must reach out to, hire, and provide equal opportunity to qualified people with disabilities1. To help us measure how well we are doing, we are asking you to tell us if you have a disability or if you ever had a disability. Completing this form is voluntary, but we hope that you will choose to fill it out. If you are applying for a job, any answer you give will be kept private and will not be used against you in any way.

If you already work for us, your answer will not be used against you in any way. Because a person may become disabled at any time, we are required to ask all of our employees to update their information every five years. You may voluntarily self-identify as having a disability on this form without fear of any punishment because you did not identify as having a disability earlier.

How do I know if I have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Blindness
  • Deafness
  • Cancer
  • Diabetes
  • Epilepsy
  • Autism
  • Cerebral palsy
  • Schizophrenia
  • Muscular dystrophy
  • Bipolar disorder
  • Major depression
  • Multiple sclerosis (MS)
  • Missing limbs or partially missing limbs
  • Post-traumatic stress disorder (PTSD)
  • Obsessive compulsive disorder
  • Impairments requiring the use of a wheelchair
  • Intellectual disability (previously called mental retardation)
Reasonable Accommodation Notice

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Share this job: