Pardes Biosciences is a clinical-stage biopharmaceutical company created by and for this moment to help solve pandemic-sized problems, starting with COVID-19. We are applying modern reversible-covalent chemistry as a starting point to discover and develop novel oral drug candidates while reimagining the patient journey to access these medicines. By capitalizing on emerging patient-friendly innovations from telehealth to new at-home diagnostic tools, Pardes is cultivating and harvesting the fruits of systemic change. We believe it is a privilege, and our responsibility, to help stop a pandemic and start a movement. We are on a mission to help patients everywhere get well sooner.

We are a virtual company with hubs in the San Francisco Bay Area, Greater Boston and Greater San Diego. All of our roles are remote at this time. It would be fantastic if candidates are located by our hubs but not a requirement. Candidates must be located in the United States.


We are seeking a highly skilled and motivated Director, DMPK to join the Translational Sciences team at Pardes Biosciences. The primary responsibilities for this position will be to develop strategies and oversee DMPK (drug metabolism and pharmacokinetics) activities to progress Pardes programs from lead identification, optimization through early and clinical development to approval. Level can be flexible based on experiences.  


  • Represent the ADME, PK/PD and Clinical Pharmacology discipline in project teams, collaborate with cross-functional teams of biology, chemistry, translational sciences, and clinical development in nominating and advancing the drug candidates from discovery through early and clinical development to approval.
  • Responsible for leading the design and execution of preclinical in vitro and in vivo DMPK studies, interpreting and translating preclinical data to the prediction of clinical PK, PK/PD and safety, and supporting the design of clinical pharmacology studies and dose selection of the late phase clinical trials.
  • Accountable for identifying and employing new ideas and approaches that address the nonclinical and clinical project issues related to the DMPK sciences
  • Work with subject matter external partners to support the application and integration of modeling and simulation tools to efficiently advance the clinical candidate selection and development.
  • Author high quality regulatory documents and address regulatory inquiries.


  • PhD, Pharm D in Drug Metabolism, Pharmacokinetics, Pharmaceutical Science, biochemistry, Chemistry or related scientific discipline.
  • Minimum 10 years of biotech/pharmaceutical experience in drug discovery and/or development settings
  • Critical thinking and scientific skills with in-depth knowledge of drug metabolism, PK, PK/PD and clinical pharmacology; demonstrate strong understanding of technical aspects and methodologies for in vitro and in vivo ADME and PK evaluation; familiarity with standard ADME/PK modelling tools such as Phoenix.
  • Experience in selecting external CROs, managing and overseeing the work at CROs and partners is preferred.
  • Ability to work effectively and collaboratively with scientists on cross-functional projects teams, and comfortable to work at a fast-paced environment.
  • Excellent oral presentation and written communication skills



Unsolicited resumes sent to Pardes Biosciences from recruiters do not constitute any type of relationship between the recruiter and Pardes Biosciences and do not obligate Pardes Biosciences to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

Pardes Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind.  We are committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions are based on business needs, job requirements and individual qualifications, without regard to race, color, religion or belief, national, social or ethnic origin, sex (including pregnancy), age, physical, mental or sensory disability, HIV status, sexual orientation, gender identity and/or expression, marital, civil union or domestic partnership status, past or present military service, family medical history or genetic information, family or parental status, or any other status protected by the laws or regulations in the locations where we operate. We will not tolerate discrimination or harassment based on any of these characteristics. We encourage applicants of all ages.


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