About Omega Therapeutics:

Omega Therapeutics is a development-stage biotechnology company pioneering a new class of programmable, mRNA-encoded therapeutics to transform human medicine. The OMEGA Epigenomic Programming™ platform harnesses the power of epigenetics, the mechanism that controls gene expression and every aspect of an organism's life from cell genesis, growth and differentiation to cell death. The OMEGA platform enables control of fundamental epigenetic processes to correct the root cause of disease by returning aberrant gene expression to a normal range without altering native nucleic acid sequences. Omega’s engineered, modular, and programmable mRNA-encoded epigenetic medicines, Omega Epigenomic Controllers™, target specific intervention points amongst the thousands of validated novel DNA-sequence-based epigenomic targets we have mapped to tune single or multiple genes to treat and cure disease through Precision Genomic Control™. Omega is currently advancing a broad pipeline of development candidates spanning a range of disease areas, including oncology, regenerative medicine, multigenic diseases including immunology, and select monogenic diseases.

About the Role:

Omega Therapeutics, Inc. is seeking a Head of R&D Operations (commensurate with experience) to join our R&D leadership team.  We are looking for an individual with a passion for bringing novel medicines to patients.  In addition, the candidate must be independent and motivated, with keen scientific curiosity coupled with the pragmatic can-do attitude and sense of urgency necessary to succeed in drug discovery and development.  This role will be expected to efficiently lead and collaborate with R&D staff and senior leaders across the company, as well as effectively manage multiple projects.  The successful candidate must be comfortable working in a fast-paced, entrepreneurial environment.

They will be responsible and accountable for all aspects of operational and resource planning, analytics, laboratory facility operations, and coordination within Omega Research and Development teams.

They will provide and integrate cross functional data, planning and decision support for R&D programs, initiatives, portfolio planning, resource use and budget planning, internal and external reporting, coordination of outsourcing/contract management and support of R&D Leadership Team.  They will have broad responsibilities across all business operations in Omega Research and Development, including responsibility for identifying, proposing and executing on process improvement initiatives within Omega R&D at critical interfaces with business partners. 

Key Responsibilities:

Resource Planning, Management, and Analytics

  • Responsible for resource tracking within R&D and developing, tracking and reporting to CSO on key performance metrics, including tracking of talent acquisition progress against headcount targets, to ensure adequate resourcing for R&D portfolio support for internal and partnered programs in partnership with Finance and Human Resources
  • Proactively identify and propose trade-offs in resource allocation, program prioritization, and/or budget as needed
  • Forecast Omega R&D resources and budget needs by tracking assumptions and changes in development plans in collaboration with Program Management as a key member of Omega planning processes
  • Track Omega R&D spend (actuals) against latest forecast, keep R&D Sr. Staff informed of budget status and support financial planning, forecasts, through analysis & development of materials for internal review and submission to Finance
  • Responsible for Operational management and cross-functional planning and to facilitate support of Omega R&D portfolio, including development, tracking and integration/analysis and reporting of R&D resourcing and vendor performance metrics

Support Business Processes

  • Serve as member of the Omega R&D Leadership Team
  • Lead cross functional Omega R&D Operations team and act as interface between R&D and other stakeholder functions and across the organization
  • Provide analyses, operational and strategic planning input and decision support for Omega CSO and R&D Staff, employing project/program plans, resource needs and timelines
  • Lead R&D functional stakeholders, in collaboration with Procurement and Legal, to facilitate efficient internal vendor communication and active vendor management
  • Responsibility for administrative oversight of all Omega R&D Operational capabilities
  • Lead initiatives for Omega R&D as needed, e.g., external grant, whitepaper or collaboration proposal preparation, compilation and submission

Facilities and Laboratory Operations

  • Provide strategic oversight of research laboratory facility programs and research space management
  • Serve as a key resource, in conjunction with Quality and Compliance function, for the development and management of programs, policies, and procedures to maintain compliance with Federal, State, and local regulatory requirements impacting research

 Required Skills:

  • Demonstrated understanding of the biotech/pharmaceutical R&D continuum
  • Experience in operational planning or project management
  • Demonstrated ability working with highly skilled teams, in a fast-paced environment
  • Highly adaptable and responsive to changing technical and business needs; comfortable prosecuting multiple priorities, troubleshooting and working with dynamic timelines
  • Strong analytical problem-solving skills and ability to think strategically, creatively
  • Comfort with multiple projects and ability to prioritize among deliverables
  • Collaborative nature and team mentality with ability to execute as an individual
  • Strong capabilities in building and motivating successful teams, and establishing and managing productive collaborations with internal and external partners
  • Ability to, within a matrixed organization, e.g., influence team decisions and facilitate and manage negotiations with departmental and line function heads
  • High level of proficiency in all Microsoft Office applications, especially Excel and SharePoint, including ability to visualize data and highlight key points (mostly in PowerPoint)

 Required Qualifications:

  • Bachelor's degree in scientific discipline with an understanding of R&D, plus minimum of 10 years of professional experience
  • MBA or an advanced medical (MD) or life sciences degree (PhD)
  • Excellent verbal and written communication, collaboration and leadership skills

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