Quantitative Systems Pharmacologist

Join our team of leading drug development experts. Nuventra, a specialized consulting group, has seen year-over-year, double-digit growth for the past 5 years. Our mission is to improve human health through a deep understanding of what a drug does to a body and what a body does to a drug. We enable our clients to make better strategic decisions and improve their clinical and nonclinical study designs. Our scientific team is supported by robust corporate infrastructure, proven processes, and innovative technology solutions.  We take pride in encouraging work-life balance and providing a positive company culture. 

Nuventra Pharma Sciences is seeking a Quantitative Systems Pharmacologist passionate about using advanced mathematical modeling and computational sciences to develop and use mechanistic models of physiologically based pharmacokinetics and quantitative systems pharmacology (PBPK/QSP). This position involves using mathematical modeling and simulation approach to address the relationships between drug properties, its pharmacokinetics and the pharmacological and toxicological responses to facilitate decision making. The candidate is expected to work with a wide range of drug molecules and therapeutic areas, collaborating with clinical pharmacologists and other scientists to provide strategic suggestions to our clients. The level for this position is flexible and will depend on the qualifications of the selected candidate.

Responsibilities:

  • Contribute to or conduct PK/PD analysis and population PK modeling and simulation using industry standard software tools, including model building and refinement.
  • Contribute to or conduct Model Based Drug Development exercises for clients.
  • Assist with the design, analysis, and interpretation of studies involving sparse sampling and provide guidance to optimize PK sampling and dosing strategies.
  • Contribute to or conduct non-compartmental and compartmental pharmacokinetic analysis using Phoenix® WinNonlin® with rich sampling data as needed.
  • Assist with providing strategic advice to clients and developing clinical pharmacology strategic plans and clinical protocol development.
  • Work with other consultants to prepare and review population PK reports and other clinical pharmacology documents.
  • Assist with development and validation of programming language in R for PK, PK/PD, and population PK analyses.
  • Author clinical protocols and clinical pharmacology and pharmacokinetic sections of regulatory documents, including INDs, NDAs, briefing packets, Investigator Brochures, etc.
  • Support client’s nonclinical efforts to ensure that sufficient preclinical PK data exists to design and support clinical studies and model development.
  • Maintain current knowledge of advancements in modeling, simulation, PK, and PK/PD science, regulatory guidance documents, FDA rulings, internal SOPs, and internal guidances to be able to contribute ideas to improve technologies and procedures for PK practices.
  • Contribute to development of best-practices and standard operating procedures for PK modeling and simulation.
  • Develop and use mechanistic models of physiologically based pharmacokinetics and quantitative systems pharmacology (PBPK/QSP).
  • Use mathematical modeling and simulation approach to address the relationships between drug properties, its pharmacokinetics and the pharmacological and toxicological responses to facilitate decision making.
  • Collaborate with clinical pharmacologists and other scientists to provide strategic suggestions to our clients.
  • Demonstrate skill in computing and programming (e.g. R, Matlab, SimBiology or NONMEM).
  • Build and use PBPK or QSP models.
  • Numerical analysis focusing on differential equations and parameter optimization.
  • Use knowledge of drug delivery, ADME, pharmacology, toxicology and translational sciences to assist with models and simulations.
  • Influence decisions and experimental design by using appropriate modeling approaches that integrate all available data.
  • Develop PBPK models for large molecule therapeutics is preferred but not necessary.
  • Develop population pharmacokinetic/pharmacodynamic models using NONMEM is preferred but not necessary.

Qualifications:

  • Advanced degree in chemical, mechanical or biomedical engineering, physics, applied mathematics, scientific computing, pharmacology or related field.
  • Expertise in scientific computing and programming (e.g. R, Matlab, SimBiology or NONMEM).
  • Experience building and using PBPK or QSP models.
  • Core competency in numerical analysis focusing on differential equations and parameter optimization.
  • Evidence of broad knowledge of drug delivery, ADME, pharmacology, toxicology and translational sciences.
  • Experience in influencing decisions and experimental design by using appropriate modeling approaches that integrate all available data.
  • Experience in developing PBPK models for large molecule therapeutics is preferred but not necessary.
  • Experience in developing population pharmacokinetic/pharmacodynamic models using NONMEM is preferred but not necessary.
  • Excellent written and oral communication skills and the ability to interact effectively with scientists in other disciplines with a positive, collegial, collaborative attitude.

Benefits and Perks:

  • Great Medical, Dental, and Vision plans (Vision is covered 100% for all employees and their families)
  • 401(k) and student loan matching
  • Flexible work environment including weekly remote work options
  • Paid childbirth and childcare leave
  • Stocked kitchen with drinks, goodies, and snacks
  • Frequent company and team-building events
  • Monthly gym reimbursement
  • 8 hours of paid volunteer time-off

Diversity is a key to success. We are an equal opportunity employer and welcome applicants of all backgrounds, experiences, and perspectives.

Apply for this Job

* Required

  
  
When autocomplete results are available use up and down arrows to review
+ Add Another Education


U.S. Equal Opportunity Employment Information (Completion is voluntary)

Individuals seeking employment at Nuventra Pharma Sciences are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information in order to help us comply with federal and state Equal Employment Opportunity/Affirmative Action record keeping, reporting, and other legal requirements.

Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.


Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.