Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position
We are seeking a talented scientist with a strong background in Biophysics to join our Drug Discovery Technology Department. In this laboratory-based position (one year contract with an opportunity to renew), you will be part of a diverse team that is focused on advancing projects by collecting and interpreting biophysical assay data for ongoing discovery programs, hit identification, and hit to lead efforts. You also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to project teams and senior management. The successful candidate will have the opportunity to directly contribute in the following areas:
- Plan and execute small molecule-protein biophysical assays to characterize binding affinity and kinetics
- Identify novel chemical matter using biophysical screening techniques of extensive small molecule compound libraries
- Characterize the binding affinity and kinetics of binary and tertiary complexes of proteins and targeted protein degrader molecules
- Characterize the binding of small molecule-DNA conjugate molecules from DNA-encoded library (DEL) screening campaigns
- Evaluate new technologies and develop novel biophysical assays
- Engage in cross-functional team discussions that support our DEL screening groups, internal project teams, collaboration projects, and machine learning efforts
- Prepare reports and present data at internal group meetings
Education and Experience
- Ph.D. in Biophysics, Biochemistry, or related discipline 0 years relevant experience OR MS with 3 years relevant experience, OR BS or equivalent with 5 years relevant experience
- Experience using biophysical techniques to analyze protein-small molecule interactions
- Extensive, hands-on laboratory experience in the use of Surface Plasmon Resonance biosensors (SPR) or Grating-Coupled Interferometers (GCI)
- Expertise in the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
- Practical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferred
- Excellent communication skills and ability to present scientific rationale, key data, issues and accomplishments to other scientific colleagues
Added Quantifications
- Experience working in PROTAC-based drug discovery programs
- Experience working with molecular biology tools (PCR, qPCR, Western Blot)
- Experience with medicinal chemistry
- Good fit with Nurix culture
- The ideal candidate must be able to commit to 1year in this role.
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