Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position
Nurix Therapeutics seeks an experienced Senior Manager to join the Analytical Development and Quality Control group. The Senior Manager will oversee daily lab operations, train/mentor/supervise lab personnel, execute method development and routine/nonroutine analysis, and manage purchasing/installation/maintenance of instrumentation, equipment and consumables.
This position is onsite in The Woodlands, Texas.
Key responsibilities include:
- Oversight of analytical chemistry lab operations
- Training, mentorship, task management, and supervision of lab personnel
- Establishment of workflows for sample receipt, analysis, data reporting, and data management
- Routine and non-routine chromatographic and solid state analysis to support chemical process development
- Method development and troubleshooting for analytical characterization of drug substances, raw materials, and synthetic intermediates
- Design and execution of forced degradation and predictive stability studies
- Instrument and equipment management to include:
- Oversight of instrument installation and operational qualification
- Management of service contracts, periodic maintenance, and lab consumables
- Instrument troubleshooting and repair as needed
- Critical review of data, reports, specifications, and other documentation
- Collaboration in the development of material control strategies and specifications
- Authorship of technical documents including analytical development reports, stability reports, and storage statements
- Collaboration in multidisciplinary teams
- Management and organization of documentation and data
- Ensuring compliance with internal SOPs and lab safety procedures
- Travel up to 5%
Qualifications
- Advanced degree in a relevant scientific discipline (Chemistry, Pharmaceutics, Chemical Engineering or related field)
- BS/MS degree with 8+ years or PhD with 4+ years of industrial experience in small molecule analytical lab operations
- 2+ years of experience managing direct reports
- Expertise in liquid chromatography and gas chromatography method development, operation, maintenance, and troubleshooting is essential
- Experience in mass spectrometry, solid state characterization, and predictive stability studies is desired
- Familiarity with ICH guidelines and cGMPs
- Ability to critically interpret data and articulate technical concepts in multidisciplinary settings
- Ability to ensure assigned activities are completed in satisfaction of project timelines
- Strong interpersonal skills that foster collaboration within and outside of the organization
- Ability to travel domestically and internationally
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Application Process
Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.
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