Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position: Nurix is seeking a highly motivated and experienced Senior Scientist to join our Chemical Development team. The successful candidate will play a critical role in the development and optimization of chemical processes for the synthesis of novel therapeutic compounds. This position requires a deep understanding of organic chemistry, process development, and scale-up, as well as strong problem-solving skills and the ability to work collaboratively in a fast-paced environment.

Key Responsibilities:

  • Characterize impurity profile of the manufacturing process and conduct impurity fate and purge experiments
  • Design and conduct process characterization studies (OVAT and/or DOE) for the manufacturing process
  • Mentor and provide guidance to junior scientists and research associates.
  • Design and develop robust and scalable chemical processes for the synthesis of small molecule therapeutics.
  • Optimize reaction conditions and improve process efficiencies to ensure high yield and purity.
  • Collaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programs.
  • Troubleshoot and resolve complex synthetic and process-related challenges.
  • Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites.
  • Prepare and review technical reports, protocols, and assist in the preparation of regulatory documentation, INDs, CTAs, NDAs and MAAs.
  • Present findings and updates to internal and external stakeholders.
  • Work up to 60% of the time in the laboratory.

Qualifications:

  • Ph.D. in Organic Chemistry, Chemical Engineering, or a related field with 3+ years of relevant industry experience, or M.S. with 5+ years of experience.
  • Proven track record in chemical process development and scale-up.
  • Demonstrated experience with NDA supportive characterization studies (OVAT and/or DOE) and identification of critical process parameters (CPPs) for process validation
  • Strong knowledge of modern synthetic organic chemistry techniques and methodologies.
  • Familiarity with analytical techniques such as HPLC, NMR, and mass spectrometry.
  • Experience with process optimization, including reaction kinetics, thermodynamics, and mechanistic studies.
  • Familiarity with regulatory requirements and guidelines for pharmaceutical development.
  • Excellent problem-solving skills and the ability to work independently and as part of a team.
  • Strong written and verbal communication skills.
  • Ability to manage multiple projects and prioritize tasks effectively.

Bonus Qualifications:

  • Experience in the pharmaceutical industry, particularly in late stage process development.
  • Hands-on experience of scaling up processes in 5-20 L jacketed reaction vessels.
  • Experience in setting up and maintaining 1-20 L jacketed reaction vessels and auxiliary systems.
  • Experience in the use of Dynochem for process modeling.
  • Experience in the use of Design of Experiment software such as JMP and/or Design Expert

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

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