The successful candidate will be responsible for the execution of research activities toward the development of drug-enhanced cell-based therapies for Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy. Collaborating with the Discovery and Process Development organizations, the translational SRA/Sci I will be responsible for executing preclinical studies, analysis and interpretation of data to guide indication selection for early clinical development. 

The successful candidate will be responsible for the execution of research activities toward the development of drug-enhanced cell-based therapies for Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy. Collaborating with the Discovery and Process Development organizations, the translational SRA/Sci I will be responsible for executing preclinical studies, analysis and interpretation of data to guide indication selection for early clinical development. 

 

 

Specific responsibilities include:

  • Utilize broad technical expertise in cell and tumor immunology, biochemistry and molecular biology to investigate, develop and optimize new methods to expand mechanistic understanding of Nurix’s clinical development assets.
  • Execute translational research studies to identify cancer indications of interest for Nurix development programs.
  • Generate and characterize human tumor infiltrating lymphocytes (TIL) using traditional methods of T cell expansion, and cell culture

Education and Skills Requirements:

  • B.S. with 8+ years/M.S. with 3-4 years/Ph.D. degree in cell biology, immunology or related discipline. Industry experience is a plus.
  • Understanding of biology supporting adoptive cellular therapy as a therapeutic modality.
  • Demonstratable experience in multi-color flow cytometry panel design and characterization of cellular subsets in human blood and tissue is required.
  • Ideally, candidate will have training and/or experience in designing and implementing in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity.
  • Ability to troubleshoot and interpret complex data in an independent fashion
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
  • Excellent interpersonal, verbal and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role.
  • Collaborative spirit and ability to work with project teams, external investigators and contract research organizations.
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills required. 

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