We are seeking a talented and highly motivated computational chemist with a strong background in Structure Based Drug Design to join our team. The Nurix mission is to treat human diseases by leveraging exciting new drug discovery technologies such as targeted protein degradation. Nurix Therapeutics is based in the San Francisco Mission Bay research campus. We have a broad pipeline of partnered and in-house programs in multiple therapeutic areas, including strong multi-target partnerships with Gilead Sciences and Sanofi. 

As part of a highly integrated team of computational chemists, structural biologists, medicinal chemists and discovery biologists, you will use state-of-the-art computational software, computer aided drug design and simulation techniques to help drive hit discovery. Your creative thinking will help to push forward the frontier of modelling in targeted protein degradation, lead optimization, and DNA Encoded Library technologies. The successful candidate will independently pursue research projects, implement novel computational workflows and support a dynamic multi-disciplinary team focused on moving projects from the hit identification stage to the discovery of clinical candidates.

Qualifications 

  • Ph.D. in Chemistry, Biology, Biophysics (or related fields) with demonstrated computational chemistry focus
  • Established skills in computer aided drug design
  • Practical working experience in computational chemistry software (e.g. Schrodinger, OpenEye, others)
  • Proven track record in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design for lead optimization, free energy perturbation and molecular dynamics simulation
  • Excellent communication of design rationale, key experimental results, issues and accomplishments in appropriate verbal and written form 
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations 
  • Maintains an excellent scientific expertise in the latest developments in computational chemistry
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Ability to work effectively in a highly interdisciplinary team
  • Software development skills in a modern programming language (eg Python) a strong plus
  • Industry or comparable academic experience in the field of computational chemistry required, small molecule drug design experience preferred (2+ years)

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

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