About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.


NewLimit is seeking an experienced group leader with a background in computational biology or machine learning to lead our Predictive Modeling team. Data-driven predictive modeling is one of the key enabling technologies of our research program, allowing us to predict the outcome and prioritize the next round of experiments to guide the design of our therapies.

As a leader of the Predict Team you will:

  • Lead a team of Scientists and Engineers to develop predictive models of experimental processes while remaining involved in day-to-day execution.
  • Collaborate with our Single Cell Technology and Epigenetic Editing teams to model large-scale epigenetic reprogramming screens with single cell read-outs.
  • Develop and apply novel machine learning capabilities to model the results of functional assays and large-scale pooled-perturbation screens using single-cell multi-omics (mRNA + ATAC, scCUT&TAG) data.
  • Serve as a technical expert, taking responsibility for the execution of sophisticated predictive modeling projects and directly influencing company-level decisions.
  • Contribute to the design, decision making, and implementation of NewLimit’s technology platform.


  • PhD in Machine Learning, Computer Science, Computational Biology, or related field or equivalent industry experience (5+ years).
  • Experience leading a cross-functional team and managing direct reports.
  • Experience with machine learning applications to diverse cell biology/multi-omics datasets.
  • Demonstrated ability to enable team members with high quality code and artifacts.
  • Highly self-motivated, intellectually curious, and excited to thrive in a fast-paced, multidisciplinary, and team-oriented start-up environment.

Nice to haves

  • Track record of publications/accomplishments in machine learning at top-tier academic institutions or companies.
  • Therapeutics development experience. 
  • Familiarity and hands-on experience with single-cell multi-omics data.
  • Fluency with modern cloud computing environments.
  • Expertise in Python data science tools (Numpy, SciPy, Pandas, etc.) and deep learning frameworks (PyTorch, Tensorflow, Jax, etc).


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