NanoString Technologies is seeking a highly motivated and technology-savvy Scientist II, who will join R&D. This position will have a key role on the development of a novel new spatial profiling technology, an approach for measuring expression levels of proteins and nucleic acids in a highly multiplexed manner in specific areas of tissues (a new paradigm in Digital Immunohistochemisty and RNAScope).

The work is highly interdisciplinary and will involve working closely with biologists, hardware and software engineers, and external customers. Successful candidate must be passionate about wet-lab driven experimentations to find innovative solutions to development hurdles. Candidate must have strong analytical skills, strong oral and written communication skills, and strong track record of independent as well as collaborative research and development.

Breakdown of Responsibilities:

  • 50% Collaborative Research
  • 50% Customer Service Projects

Essential Duties:

  • Execute pathology and molecular biology protocols to validate new IHC and RNAScope assay reagents for GeoMx DSP
  • Execute experiments on the GeoMx DSP platform using IHC and RNAScope 
  • Develop standard operating procedures and test protocols
  • Organize, manipulate and analyze large complex data sets in R and/or Excel (R preferred) 
  • Manage and organize sample and reagent inventory 
  • Develop RNAScope protocols and write SOPs 
  • Effectively collaborate with other team members, including engineers, scientists, biologists, and senior management

Requirements:

  • Ph.D. in Life/Chemical/Physical/Engineering Sciences or related fields and 1+ year of related experience.
  • Strong wet bench and assay development skills related to consumable reagents development. Track-record of working with novel technologies and chemistries to improve protein and nucleic acid assays and manipulations 
  • High degree of computer literacy with frequently used software such as Microsoft Word, PowerPoint, Project Management, Excel, ImageScope and “R”
  • Experience with imaging and assays involving tissue preparations, especially FFPE (formalin fixed paraffin embedded) tissue. 
  • Extensive experience with bright field and fluorescent microscopy applied to tissue and cellular imaging. 
  • Excellent verbal and written communication skills 
  • Broad knowledge of protein and nucleic acid characterization techniques, and hybridization-based assays 
  • Experience with protein detection methodologies, proteomics, multiplexed protein assays and handling antibodies 
  • Experience with RNA and DNA sample preparation, genomics and a wide variety of nucleic acid protocols 
  • Experience with client management skills 
  • Experience with scripting and automation of laboratory equipment / microscopes for new assay workflow development 
  • Experience with fluorescence-based detection technologies including single molecule detection
  • Experience with quantitative IHC (Immunohistochemistry) ​

 

NanoString is an Equal Employment Opportunity and Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, or disability status. NanoString does not accept unsolicited agency resumes and will not pay fees to any third-party agency or company that it does not have a signed agreement with.

 Accommodations

If you require assistance or accommodation when applying for open positions please contact recruiting@nanostring.com.

NanoString is an Equal Employment Opportunity and Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, or disability status. NanoString does not accept unsolicited agency resumes and will not pay fees to any third-party agency or company that it does not have a signed agreement with.

 Accommodations

If you require assistance or accommodation when applying for open positions please contact recruiting@nanostring.com.

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