We are hiring a Senior Director, Preclinical Programs to build and lead in vivo therapeutic programs for genetically driven rare inherited diseases (CNS, liver, metabolic, hematology).  Reporting to the Senior Vice President, Preclinical, you will leverage your strong technical leadership, and expertise in preclinical development of gene editing drugs to guide in vivo study design to drive our in vivo gene editing programs.  This position is located in Emeryville, California. 

How you'll contribute

  • Provide strategic direction to the executive team and external collaborators regarding the in vivo platform, including in vivo study design 
  • Establish scientific standards and set strategic direction and priorities for gene editing strategies
  • Collaborate with the Chief Medical Officer to understand and plan for clinical translation and establish pre-clinical criteria for development candidate selection
  • Partner with Discovery and Protein Engineering groups to leverage advances in the gene editing platform for therapeutics
  • Provide scientific leadership by proactively advising, sharing knowledge and expert opinions across functions and with senior management
  • Work closely with project teams to ensure timely execution and communication of research results with high-quality standards, enabling clear go-no/go decisions and timelines.
  • Anticipate scientific barriers and proactively develops strategies to ensure the successful selection of development candidates
  • Oversee the development and execution of assays and studies (efficacy and mechanism of action) to enable the in vivo gene delivery platform and support drug candidate nomination and selection.
  • Apply experience and expertise in preclinical development of gene editing drugs to guide in vivo study design
  • Develop and execute a hiring plan to support internal and partnered programs; attract and retain outstanding scientistific talent, (Scientist level and above) who lead therapeutic programs 
  • Present progress updates to key decision-makers, including partners, research, and management teams.

What you bring:

  • Ph.D. in Cell or Molecular Biology, Pharmacology (or closely related field) and at least ten years of experience managing senior-level scientists
  • Demonstrated experience in drug discovery in gene editing or gene therapy for rare inherited diseases (CNS, liver, metabolic, hematology)
  • Experience leading and managing external biopharma partnerships
  • Experience in pharmacokinetics, toxicology, and animal pharmacology/monitoring animal studies
  • Experience writing/reviewing regulatory sections of successful INDs
  • In-depth experience managing CROs to achieve nonclinical milestones on time and within budget
  • Comprehensive knowledge of the drug development process, including cross-functional integration from animal preclinical POC through Phase I
  • A transparent, flexible, can-do leadership approach to address issues innovatively and proactively to promote teamwork and a positive work environment 
  • Outstanding influencing, oral, and written communication skills.

California Pay Transparency Disclosure:

This position is classified as an exempt position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $250K-$280K.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.

#LI-NG1

 

 

About Metagenomi

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.

 

What makes Metagenomi a unique place to work?

  • We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.
  • We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more! 
  • We offer competitive compensation including a market-benchmarked salary, annual target bonus potential, pre-IPO equity, and a comprehensive benefits plan, including 401(k) with company matching, a retirement safe harbor plan, and other perks.

 

At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.

 

Applicants/Employees have rights under various State and Federal Employment Laws, including

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Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.

 

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