About Maze Therapeutics   

Maze is a clinical-stage biopharmaceutical company harnessing the power of human genetics to transform the lives of patients through the development of a pipeline of novel precision medicines for patients with genetically defined diseases. Maze is leveraging Compass™, a proprietary, end-to-end purpose built platform to advance a pipeline of precision medicines across four disease areas - renal, cardiac, neurological and metabolic diseases. Our flexible business model aims to translate our genetic insights into as many new therapies for patients as possible.  

Our People  

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.    

Our Core Values  

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.   

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.  

Stand True – Our integrity is foundational; it guides us no matter the obstacle.  

Role Description: 

The DMPK department is seeking a qualified Drug Metabolism Senior Research Associate with experience running various in vitro assays (e.g. metabolic stability, CYP inhibition and PPB using equilibrium dialysis). Work will entail extensive use of LC-MS/MS and LC-HRMS systems for measurement of small molecules. Experience with high resolution mass spectrometers is a plus.  

Your Impact Includes: 

  • Executing in vitro DM assays such as hepatocyte and microsomal stability, CYP inhibition, and plasma protein binding using RED device. Samples will be analyzed by LC-MS, data processed, QC’ed and uploaded. 
  • Working closely with other members of DMPK group, discovery project teams and Research Infrastructure group to ensure that assays are run according to agreed timelines.  Data presentation required. 
  • You will troubleshoot methods and instrumentation and help perform routine LC-MS maintenance.  Experience with laboratory automation a plus. 
  • Collaborate with CROs to perform outsourced and overflow work. 
  • Understanding of the relationships of DMPK principles is a plus 


  • BA/BS/MS with 5+ years’ experience working with LC-MS systems within a pharmaceutical company, academic institution or CRO. 
  • A minimum of 2 years of experience working in DMPK field, preferably running in vitro assays. Must demonstrate solid knowledge of drug metabolism concepts. 
  • Will require working independently and meeting timelines.  Ability to troubleshoot assay and LC-MS performance is key. 
  • Keen attention to detail, excellent communication skills and ability to work in a team-based environment are essential. 
  • Thrives in a collaborative and independent setting.  


The expected salary range for this role for employees located in the San Francisco bay area is $99,500 - $115,200. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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