Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.


We are seeking a highly-motivated, proactive individual to manage, maintain, and evolve operations for a 30-person team at Manifold Bio. This position reports directly to the CEO and will oversee general operations, including finance, legal, HR, and hiring. We have a strong ownership culture, and you will be responsible for empowering and supporting our scientific team to perform cutting-edge R&D. We are on an ambitious mission to redefine therapeutics discovery, and operations excellence is crucial. The best candidate will bring thoughtful long-term vision and planning combined with the ability to roll up your sleeves and problem-solve as needed.


  • Be a strategic thinker to enable the organization as it scales, advise employees navigating essential topics, and be a strong collaborator with critical functional partners.
  • Communicate recommendations and decision-making process to the CEO to enable efficient and optimal operational evolution
  • Own financial functions (reporting and projections) directly and/or in collaboration with consultants
  • Oversee the recruiting function by establishing clear internal alignment on new roles and helping manage and evolve our hiring process.
  • Own the implementation of performance management and compensation decisions, with the aid of consultants as needed
  • Ensure awareness of and compliance with state and federal regulations related to finance, HR, and other responsibilities

Required Qualifications

  • Bachelors or Masters and 5+ years of experience in operations (biotech / pharma strongly preferred)
  • Pragmatic and efficient problem solver and decision maker, knowing when to roll up your sleeves and when to outsource
  • Has owned operations responsibilities in a startup of less than 50 people, as well as larger organizations
  • Self-motivated, highly organized, proactive, and able to multitask
  • Experience creating and implementing new operations procedures and processes
  • Process-driven and detail-oriented, and good at inspiring others to follow procedures
  • Service-oriented mindset with a love for enabling teams and individuals
  • Collaborative, curious, and flexible with strong communication skills, both written and oral
  • Skilled with relevant software tools (Google Drive, Powerpoint, Excel, etc.)

Preferred Qualifications

  • Background/expertise in financial planning and owning a multi-million dollar budget
  • Operational experience scaling a biotech startup


 Highly competitive additional benefits package across healthcare, paid time off, commuter benefits, and company-provided lunch every day.


We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
When autocomplete results are available use up and down arrows to review
+ Add another education

Please reach out to our support team via our help center.
Please complete the reCAPTCHA above.