At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage it reflects who we are and the environment we are creating.


The incumbent will support the ongoing operation of the Manufacturing, Science and Technology team within the manufacturing site.  This role will assist the receipt of technology transfers into manufacturing, and critical manufacturing support activities including investigations, change controls, CAPAs, process capability, capacity, electronic batch records, efficiency and quality improvements.


Equipment Identification, Qualification, and Support

  • Work with a cross-functional team to ensure appropriate equipment selection and procurement.
  • Facilitate equipment installation, commissioning, and qualification.
  • Provide technical support of equipment during the onboarding phase and during ongoing operations.

Product, Process, and Technology Transfers and Changes

  • Execute transfers of new products and processes to ensure smooth transition from process development into GMP manufacturing.
  • Train Manufacturing staff as necessary on new unit operations and processes being transferred.
  • Provide support for the MSAT team and cross-functional project teams in areas of facility fit, gap analysis, FMEA risk assessment, troubleshooting and investigation.
  • Train MSAT engineers responsible for technology transfers and process troubleshooting.
  • Assist in documenting changes/updates to manufacturing processes and work with cross-functional teams to implement those changes.
  • Support the development, validation, and revision of electronic batch records as needed.
  • Author and review, as necessary, sections of the regulatory documents and other communications to government authorities.

Investigations and Technical Support

  • Provide technical support for deviation management, lot disposition, batch record reviews so that technical issues stay off the critical path for reliable supply.
  • Provide real-time technical support to operations.

General Responsibilities

  • Identify opportunities to implement operational excellence and continuous improvement.
    • Maintain appropriate level of training for assigned responsibilities.
    • Identify, communicate, and help mitigate identified risks that could negatively impact the quality or delivery of patient therapies.
  • Assist with CAPA and change controls as needed.

Collaborate Effectively

  • Build strong relationships with Quality to ensure a compliant manufacturing environment.
  • Be a team player, offer assistance, and respond well to requests for help from team members.
  • Use good communication and build relationships.
  • Demonstrate technical acumen, operational understanding, and GMP compliance.
  • Support operational excellence initiatives.
  • Promote a culture of safety and GMP compliance.
  • Identify opportunities for continuous improvement.



  • BSc degree in a relevant field (eg biochemistry, chemical engineering, bioengineering, or related scientific field), a Master’s degree is a plus


  • Minimum 8+ years (6+ years w/MS in relevant field) of experience in support of cell culture and upstream operations for GMP biopharmaceutical manufacturing with 2+ years supporting cell or gene therapy manufacturing.
  • Experience in technical roles within a GMP biopharmaceutical manufacturing operation, experience working in process development is a plus.
  • Experience with manufacturing automation and MES software systems.
  • Experience with quality management systems (e.g. Deviations, CAPAs, Change Management).


  • Working knowledge of USA and global regulations for GMP manufacturing of drug substance, drug products, cellular and gene therapies, including requirements for clinical phase appropriate validation/qualification.
  • Strong collaboration and influencing skills, with demonstrated ability to problem solve and drive positive change.
  • Proficient in MS Office and statistical software (R, JMP or Minitab).
  • Proven ability to effectively lead projects in a fast-paced environment.
  • Excellent written and verbal communication skills.
  • Proven track record in a cGMP environment.
  • Fast learner, adaptable, and excellent cross-collaboration and inter-personal skills.
  • The desire and ability to work in a fast-paced, start-up environment.

Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.

The salary range for this position is $130,000 to $145,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.

Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found here.

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
When autocomplete results are available use up and down arrows to review
+ Add Another Education

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Lyell Immunopharma’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.