At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Respect, Science, Courage and Collaboration and it reflects who we are and the environment we are creating.
 

SUMMARY:

We are seeking an experienced Research Associate to join our In Vivo Pharmacology team in Pathology & Nonclinical Development. The group’s mission is to evaluate the efficacy, mechanism, and safety of our novel T-cell therapy candidates in vivo pharmacology studies using various mouse models, providing excellence and support to the Lyell Research groups and to our development pipeline projects. This position will play a key role in setting up, executing, and reporting our in vivo pharmacology studies, and collaborating with scientists across Lyell.

KEY ROLE AND RESPONSIBILITIES:

  • Maintenance of highly functioning in vivo and ex vivo labs, working with the other members of the In Vivo Pharmacology group and other cross-functional scientists.
  • Proficient in basic animal handling, including necropsy and organ/tumor sample collection.
  • Setup and execution of in vivo studies using xenograft and syngeneic mouse models of solid tumors including animal preparation/surgery, tumor implantation (s.c., i.p., or orthotopic), preparation and dosing of therapeutic human T cells and other agents via various routes of administration, tracking of tumor growth by caliper measurements, collection of blood and tumor samples, and monitoring of animal health.
  • Ex vivo study responsibilities include cell culture, collection and processing of organs and tumor samples for immunological and pathological analysis
  • Collection, entry, analysis of study data , and presentation to project teams
  • Generation and maintenance of electronic lab notebook (ELN) reports, including basic statistical data analysis.

PREFERRED EDUCATION:

  • BSc in biotechnology, molecular biology, microbiology, immunology, oncology, or related field with minimum 7 years experience within the area of focus OR
  • MSc in biotechnology, molecular biology, microbiology, immunology, oncology, or related field with minimum 5 years experience within the area of focus

PREFERRED EXPERIENCE:

  • Proficient in executing various xenograft and syngeneic tumor models using immunocompromised (NSG-MHC-dKO) and immune-competent mice with adoptive T cells
  • Proficient with mammalian cell culture techniques such as cell line passaging, cryopreservation and cell thawing, and cell counting
  • Experience with complex flow cytometry assays and analysis
  • Experience with live animal imaging modalities (eg., bioluminescence/fluorescence, micro-CT)
  • Experience in data production and report writing for external publications and regulatory filings
KNOWLEDGE, SKILLS AND ABILITIES:
  • Experience using and analyzing common immunology and oncology related to the specific project; cell therapy experience is ideal, more complex experience a plus
  • Proficient in sterile tissue culture technique and experience working with human cells
  • Additional specific experience related to the area of focus may be required
 
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
 
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
 
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

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