At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.

This role resides in the Vector Sciences group with the Technical Operations function at Lyell. You will work collaboratively within the Vector Sciences project team and supports technological transfers to the LyFE manufacturing facility in Bothell in collaboration with Lyell’s MSAT team to support the production pipeline.  In this role you will provide technical leadership for viral vector downstream process development and characterization to support clinical and commercial manufacturing. The responsibilities also include authoring technical reports, process transfer documents, process control strategy and process related documents.

The scientist is responsible for keeping abreast of current publications in their field and can independently integrate ideas from these publications into current projects. Networks with colleagues outside their own area of expertise.


  • Optimize downstream processes for lentiviral manufacturing using liquid chromatography unit as well as filtration operations
  • Design and execute downstream process development studies to support viral vector clinical manufacturing process
  • Data analysis related to downstream processes and assays and experimental outcomes
  • Development of novel downstream processes for viral products
  • Perform normal flow and tangential flow filtration operations, chromatographic separations, in-process analytical testing as required
  • Developing GMP downstream processes and assay development and performance regarding downstream development
  • Leading and assisting in research, product and process development for current and novel work which includes hands-on work
  • Writes, reviews, and approves R&D protocols, batch records, and reports in support of RD, process development.
  • Write SOPs, work instructions, test methods, and other product development and R&D documents
  • Author and review technical reports, process descriptions, process control strategy and process related documents
  • Support technology transfer of clinical and/or commercial process
  • Collaborate with Upstream, Analytical, Formulation, Drug Product and MSAT team to support ongoing pipeline products
  • Participate and influence the cross functional team to advance CMC activities
  • Coordinates lab work with members of the vector development team
  • Ability to work independently with minimal or no supervision
  • Communicate and discuss results with other scientists
  • Delivers presentations and contributes to abstracts, posters or publications, both internally and externally
  • Responsible for mentoring and possibly managing junior associates
  • Can be involved in steering the scientific direction of external collaborations


  • MSc in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline with a minimum of 9 years’ experience within the area of focus; or
  • PhD in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline of 4 years’ experience within the area of focus.


  • As a Scientist II the scientist must be skilled and accomplished in downstream viral vector processes 
  • Field and execute all scientific research and development strategies independently while collaborating with Upstream and PD/MSAT teams. The candidate needs ample experience in downstream unit operations such as vector harvest, liquid chromatography, and TFF.
  • Extensive knowledge and experience in the field of software used in chromatography and filtration steps. The candidate needs to have demonstrated knowledge of process design, optimization, and characterization for early to late-stage programs.


  • Skilled and accomplished in the field of downstream vector molecule processing, preferably of lentiviral vectors
  • Experience in developing downstream processes for GMP manufacturing and/or working experience in GMP facilities performing downstream operations  
  • In-depth knowledge of software used in planning and controlling instruments used for liquid chromatography and tangential flow filtration (i.e. Unicorn, KF Komm)
  • Experience with electronic lab notebooks
  • Able to design complex experiments with scientific rationale
  • Understands the theoretical basis and experimental objectives and how they fit into the overall project goals; uses broad knowledge of current literature to drive the direction of the project
  • Able to critically analyze and interpret data
  • Developing skills in critical interpretation of scientific data and problem solving and reporting of scientific data
  • Knowledgeable and deeply proficient in a range of technical skills and the ability to teach junior colleagues
  • Highly proficient in using Microsoft Office (Word, Excel, PowerPoint)
  • Effectively communicate and discuss results with other scientists on the team; general comfort with presenting data across the company and externally
  • Strong ability to work in a matrixed environment


  • Prolonged periods sitting of at a desk and working on a computer and standing, reaching and bending

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
When autocomplete results are available use up and down arrows to review
+ Add Another Education

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Lyell Immunopharma’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.