The Role:

Life Edit Therapeutics is looking for a proven in vivo CNS pharmacologist with strong organizational, communication, and strategic skills, and the desire to be part of a highly collaborative and cross-functional team. The applicant will apply their pharmacology knowledge and expertise to drive product development for our in vivo gene editing CNS therapeutic programs. This position offers an exciting opportunity to contribute to the preclinical development of a variety of gene editing products and to help build a successful therapeutics company.


Here’s What You’ll Do:

  • Drive the strategy, and identify and oversee the development and/or implementation of clinically relevant CNS animal models for testing gene editing therapeutic candidates
  • Provide critical input in the evaluation of applicable gene-editing CNS targets and direction in feasibility for in situ-in vitro-in vivo translation through to support of regulatory enablement and clinical development
  • Design, hands-on execution as it relates to studies that require advanced technical skillsets and or oversight, and interpretation of CNS preclinical studies
  • Identify clinically meaningful fluid and imaged based biomarkers
  • Support the justification of the first-in-human dose with associated benefit/risk assessment
  • Communicate and collaborate cross functionally to ensure timely and effective implementation of programs in a regulatory ready research environment
  • Identify and collaborate with preferred CROs and academic groups during all aspects of execution of preclinical studies (study design, monitoring, data analysis, interpretation, and reports for regulatory filings)
  • Manage preclinical scientist direct reports
  • Ensure compliance with good laboratory practices and other regulatory guidelines
  • Monitor, review and critically interpret published literature to guide research and regulatory strategy
  • Develop cellular target and indication-specific delivery systems with an administration route that will readily transfer to the clinical setting



  • PhD in Neurobiology, Toxicology, Pharmacology, or related life sciences field with strong scientific background and 10+ years’ relevant experience; OR a master’s and 15+ years’ relevant experience
  • Extensive experience compiling study reports
  • Adept knowledge of CNS biologics or gene therapy development
  • Extensive knowledge in neurobiology, clinically relevant CNS models and drug development
  • Experience in the design, execution, interpretation, and report tabulation of CNS in vivo preclinical studies (including experience with both rodent and NHP animal models)
  • Experience with dosing and delivery of biologics, including AAV, via multiple CNS routes
  • Experience managing external vendors and coordinating outsourced preclinical studies
  • Experience managing direct reports, CROs, and collaborating with project teams
  • Ensure appropriate use of animals in compliance with the 3Rs: Replacement, Reduction and Refinement
  • Team player, detailed oriented, and outstanding organizational and communication skills (verbal, presentation, and written)
  • Ability to manage multiple projects in a fast-paced environment
  • Ability to effectively collaborate in a dynamic, cross-functional matrix environment


Preferred Qualifications:

  • Industry experience strongly preferred
  • Experience with CNS and/or ocular disorders is desirable
  • Experience with gene therapy and/or gene editing

Why join Life Edit Therapeutics?

Life Edit Therapeutics, an ElevateBio portfolio company, is a gene editing company on a mission to rewrite the future by curing disease, making any edit, anywhere. Life Edit has built a world-class genome editing platform with one of the world’s largest and most diverse collections of novel RNA-guided nucleases (RGNs) and base editors. The company’s next-generation editing systems will propel the development of novel human therapeutics by enabling ex vivo engineering for cell therapies and regenerative medicines and in vivo delivery of gene therapies.

Our Vision:  To pave the way to faster, safer, gene editing therapeutics that cure disease and improve patient lives

Life Edit is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Life Edit will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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