Research Associate/Scientist, Immunology
Kernal Bio is creating mRNA drugs that instruct specific cells in the body on how to make their own medicine. Messenger RNA technology has proven extremely useful in rapidly developing vaccines against COVID. Kernal is developing the next generation of mRNA therapy, called mRNA 2.0. It solves a critical problem of cancer cell selectivity that affects mRNA and oncolytic virus-based immuno-oncology drugs. Located in Cambridge, MA, Kernal received three awards from Amgen and NASA. With roots at MIT, Harvard, and Big Pharma, Kernal’s interdisciplinary team of MDs and PhDs previously built a successful Biotech company and has deep expertise in mRNA space.
Kernal Bio is seeking an exceptional, highly motivated Research Associate Scientist/Scientist to contribute to development of its mRNA 2.0 platform for therapeutic applications. The successful candidate will work as part of the team responsible for testing mRNA in vitro and in vivo preclinical models. Candidate should have experience working with murine models of cancer.
- Perform procedures in mice with primary focus on in vivo anti-tumor efficacy, PK/PD, and MOA studies for drug candidates
- Perform standard and complex in vivo procedures including dosing all routes, tumor inoculation, tumor measurements and tissue necropsy.
- Ex vivo analysis of immune cells from tumor and tissues, including collection and processing of multiple samples. Analysis of immune cells using multicolor flow cytometry
- Perform routine mammalian cell culture and transfection
- Analyze, summarize, and present experimental results to team members and management
- Contribute to technical discussions & intellectual property related to the development and application of Kernal’s proprietary technologies
- Explore new technologies and methods to optimize current processes in a fast-paced research environment
- Maintain up-to-date records and communicate results to team members in written technical reports and oral presentations
- Participate in experimental design and troubleshooting efforts
- Interpret, summarize experimental data and maintain excellent laboratory notebooks
- BS/MS with 4+ years of experience, preferably in industry setting, or PhD in life sciences.
- Hands-on in vivo experience with rodents, particularly in oncology setting
- Proficient in cell transfections, ELISA, MSD, flow cytometry.
- Excellent interpersonal and collaborative skills and the ability to work independently and effectively in a dynamic team environment.
- Strong written and verbal communication skills
- Excellent record keeping and data management skills
- Adaptability and enthusiasm for new challenges, innate curiosity and a passion for learning
- Experience working in fast-paced startup environments
- Excellent organization skills, approaching tasks with efficiency
- Ability to analyze, summarize and communicate scientific data
- Competitive 401(k)
- Highly competitive healthcare coverage
- On-site subsidized cafeteria
- Free parking, monthly subway pass or a subsidized commuter rail pass
- Free MIT Athletic Membership
- Free Bluebikes Membership
- Flexible Spending Account
- Paid parental leave, family caregiver leave, medical leave