Medicinal Drug Design Lead, London

Please note: you may have noticed that we have two drug design adverts open at the moment, within two of our Drug Design Teams: ‘Medicinal Drug Design’ and ‘Synthetic Drug Design’. We would recommend that you read both carefully and ideally only apply to the one that is most relevant to your experience and most aligned with the area where you feel you could have the biggest impact. If you feel strongly that you could suit either equally well please include a note explaining this - either in a cover letter, or in the field on the application form that asks ‘Is there anything else you’d like us to know?’ - and apply to both. Thanks, and good luck with your application.

About Isomorphic Labs

Isomorphic Labs is a new Alphabet company that is reimagining drug discovery through a computational- and AI-first approach.

We are on a mission to accelerate the speed, increase the efficacy and lower the cost of drug discovery. You'll be working at the cutting edge of the new era of 'digital biology' to deliver a transformative social impact for the benefit of millions of people. 

Come and be part of a multi-disciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring, collaborative and entrepreneurial culture.

About the Medicinal Drug Design Team

We are a growing team of medicinal chemists who sit within the Drug Design and Medical Research function at Isomorphic Labs. Our primary focus is to lead the chemistry on our internal portfolio and collaboration projects, but we also use our domain knowledge to work collaboratively with our AI/ML colleagues to build the Platform and drive forward success and innovation in drug design. We work closely together in a supportive environment, where everyone is valued for the expertise and experience they bring to the group. We have a strong growth mindset and ensure we prioritise continued development and learning as medicinal chemists. 

Your impact 

As part of the ongoing expansion of our Drug Design and Medical Research function, we are looking to recruit a number of Medicinal Chemistry positions in our Medicinal Drug Design Team.

Working as part of the Medicinal Drug Design Team, you will work as a chemistry lead to deliver scientific expertise and strategic direction to fulfil milestone objectives on our portfolio projects. You will be supporting the business alongside world leading AI/ML Drug Design Platform teams, and  will work collaboratively to drive both improvements in the Platform and apply this to real drug design projects. 

If you are a skilled and ambitious scientist looking to take the next step in your career, joining Isomorphic Labs now will lift you out of your comfort zone and provide you with an amazing opportunity for personal growth and development. 

Please note that there is some degree of flexibility around the level of seniority in the position - you’re ideally somewhere between Research Scientist and Research Leader but we will need you to take an active hands-on role as an individual contributor rather than being a people manager.

What you will do 

  • Apply your knowledge and track record of modern drug design / discovery principals and synthetic organic chemistry to execute Drug Design programs and to provide strategic input and technical direction to our Platform teams. 
  • Collaborate both internally and with third party organisations, interacting within multidisciplinary teams, to support data-driven delivery of high quality scientific solutions to complex technical problems. 
  • Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organisations (CROs). 
  • Manage CRO resource and other members of the growing team, mentoring and supporting their development. 
  • Prepare detailed scientific proposals and reports to support new and ongoing programs. 
  • Embrace and champion our culture of inclusion and continuous professional development. 

Skills and qualifications 

Essential:

  • PhD in Chemistry or a related technical field, or equivalent experience.
  • Good foundation in medicinal chemistry with a minimum of 5+ years previous industrial experience operating as an individual contributor within a pharma/biotech/CRO setting. 
  • Experience in execution of drug discovery programs from HitID to Candidate delivery with a consistent track record, working in multidisciplinary teams. 
  • Experience in a lead chemist role. 
  • Experience and expertise working on Lead Optimisation programs, with familiarity of optimisation of Drug Metabolism and Pharmacokinetics (DMPK). 
  • Experience of working with and closely managing CRO resource. 
  • Track record of authorship of relevant scientific manuscripts and inventorship of composition of matter patents. 

Nice to have:

  • Direct experience of working in a Pharma, Biotech or CRO on drug discovery collaborations, ideally in a chemistry or project lead role. 
  • Experience of contributing to Structure-Based Drug Design problems. 
  • Experience of successful application of fragment-based drug design approaches.


Culture and values

What does it take to be successful at IsoLabs? It's not about finding people who think and act in the same way, but we do have some shared values:

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

In this together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.


Creating an inclusive company

We realise that to be successful we need our teams to reflect and represent the populations we are striving to serve. We’re working to build a supportive and inclusive environment where collaboration is encouraged and learning is shared. We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact. 

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.


Hybrid working

It’s hugely important for us to be able to share knowledge and establish relationships with each other, and we find it easier to do this if we spend time together in person. This is why we’ve decided to follow a hybrid model, and for full time positions we would require you to be able to come into the office 3 days a week (currently Tue, Wed, and one other day depending on which team you’re in). For part time positions this may vary.  As an equal opportunities employer we are committed to building an equal and inclusive team. If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.


>> Click to view other open roles at Isomorphic Labs

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We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact. We are working to build teams that reflect and represent the populations we are striving to serve. As part of this effort we would like to better understand our candidate audience, so that we can continue to improve.

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If you have any questions about the form contact us: joinus@isomorphiclabs.com.

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