Leader of DMPK and Physical Sciences, London

Isomorphic Labs is a new Alphabet company that is reimagining drug discovery through a computational- and AI-first approach.

We are on a mission to accelerate the speed, increase the efficacy and lower the cost of drug discovery. You'll be working at the cutting edge of the new era of 'digital biology' to deliver a transformative social impact for the benefit of millions of people. 

Come and be part of a multi-disciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring, collaborative and entrepreneurial culture.

Your impact 

This is an exciting opportunity to work closely with world leading AI and ML experts to develop imaginative new ways to predict ADMET and human dose to drive projects forward. You will have accountability for all the ADMET strategies from early Drug Discovery through to Candidate Selection and ultimately to Clinical Phase work across numerous therapeutic areas.

We are seeking a candidate who is highly experienced, with significant management experience, working across drug discovery projects, driving them to Candidate Selection and preferably to clinical phases of development.

What you will do 

  • Set the company DMPK strategy across the project portfolio
  • Lead a small team of DMPK scientists to deliver on Drug Discovery projects
  • Work with CROs to deliver the highest quality ADMET data and reports
  • Distil ADMET data into actionable insights for project leaders, project team members, and potential collaborators
  • Be closely integrated in projects to provide strategic input into the project direction
  • Prepare relevant internal and regulatory documentation for preclinical and clinical work
  • Apply PK-PD modelling work to set dosing strategies for in vivo efficacy models, and to provide early human dose projections
  • Work cross functionally with Medicinal Chemistry, Biology, and Technology groups

 

Skills and qualifications 

Essential:

  • BSc, MSc or PhD in Biochemistry/Chemistry/Pharmacology/Pharmacokinetics and likely be highly experienced (>10 years) in the pharmaceutical industry
  • Expert knowledge are DMPK concepts such as Tier 1/2 ADMET assays, Transporters, Drug Metabolising Enzymes and Transformations, IVIVC/IVIVE, Pharmacokinetics, PK-PD relationships, mechanistic and allometric scaling approaches to Human Dose Projections
  • Proven track record of influence on projects such as de-risking strategies, anticipating longer term issues, solving ADMET issues and driving change in Medicinal Chemistry SAR strategies
  • Experience of working in multiple therapeutic areas and by multiple routes of administration
  • Experience working with Toxicology, Translational, Formulation, Clinical Pharmacology in setting clinical strategies
  • Experience leading the DMPK group/department
  • Driven and focussed mindset to achieve the goal of Candidate delivery in the most efficient manner through robust discussions with key stakeholders and project leaders
  • Dynamic, agile, and flexible individual who can work across therapeutic areas, and multi-disciplinary teams
  • Experience working with and assisting CROs in acquiring high quality ADMET data in a timely manner
  • Collaborative and inclusive mindset to partner across teams to drive shared learning

Nice to have:

  • Experience working for a CRO providing ADMET services
  • Knowledge/Concept of computational chemistry machine learning modelling
  • Good understanding of Medicinal Chemistry concepts and comfortable discussing small molecule approaches and strategies
  • Experience working with Data Science groups in setting up assay templates for ingestion of ADMET data


Culture and values

What does it take to be successful at IsoLabs? It's not about finding people who think and act in the same way, but we do have some shared values:

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

In this together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.


Creating an inclusive company

We realise that to be successful we need our teams to reflect and represent the populations we are striving to serve. We’re working to build a supportive and inclusive environment where collaboration is encouraged and learning is shared. We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact. 

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.


Hybrid working

It’s hugely important for us to be able to share knowledge and establish relationships with each other, and we find it easier to do this if we spend time together in person. This is why we’ve decided to follow a hybrid model, and for full time positions we would require you to be able to come into the office 3 days a week (currently Tue, Wed, and one other day depending on which team you’re in). For part time positions this may vary.  As an equal opportunities employer we are committed to building an equal and inclusive team. If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.


>> Click to view other open roles at Isomorphic Labs

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We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact. We are working to build teams that reflect and represent the populations we are striving to serve. As part of this effort we would like to better understand our candidate audience, so that we can continue to improve.

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