Generation Bio is innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases. The company is developing two distinct and complementary platforms: a potent, highly selective cell-targeted lipid nanoparticle (ctLNP) delivery system and a novel immune-quiet DNA (iqDNA) cargo produced by a scalable capsid-free manufacturing process that uses proprietary cell-free rapid enzymatic synthesis (RES). With these platforms, Generation Bio aims to develop the next wave of non-viral genetic medicines to support its mission to extend the reach of genetic medicine to more people living with more diseases, around the world.  

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.  

Delve further.  Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/ 

SUMMARY:

Generation Bio is seeking an energetic and highly motivated Scientist to join the Immunology team within the Discovery Research group. The position will play a key role in development and evaluation our cell targeted lipid nanoparticle (ctLNP) delivery platform by developing and executing in vitro assays aimed at evaluating ctLNPs interacting with immune cells. The position will play a key role in evaluating our cell targeted lipid nanoparticle (ctLNP) delivery platform by designing, executing, and analyzing in vitro assays aimed at evaluating ctLNPs interacting with immune cells. The ideal candidate will have a strong background in cell based assays (such as, but not limited to immune-assays and ELISAs, experience isolating and maintaining primary immune cells, T cell activation/differentiation, and flow cytometry). Responsibilities will also include cross-functional research to enable early program development for indications in target cell types.

RESPONSIBILITIES:

  • Contribute to the design, optimization and execution of assays to assess ctLNP interactions with primary immune cells
  • Work with Preclinical Group to evaluate novel ctLNPs and target biologies for new platform technologies
  • Perform a range of biochemical techniques such as ELISA, MSD, qPCR and flow cytometry to characterize protein and RNA expression and function.
  • Design experiments, analyze data and interpret results
  • Summarize work in written reports and oral presentations
  • Maintain accurate and up-to-date laboratory records

QUALIFICATIONS:

  • Experience in the fields of immunology or cell biology (or related)
  • PhD, MS with a minimum of 6 years of related experience, or BS with a minimum of 8 years of related experience, industry experience preferred.
  • Demonstrated leadership and hands on experience in primary immune cell assay development and execution
  • Experience isolating and culturing primary immune cells, such as T cells and B cells from human and/or mouse required
  • Experience with T cell assays (such as T cell activation and differentiation)
  • Knowledge of flow cytometry and multi-color panel design strongly desired
  • Experience with QPCR, western blot techniques, ELISAs, etc a plus
  • Ability to work cross functionally in a dynamic matrixed environment
  • Ability to multi-task to support multiple projects across platform discovery organization
  • Organized, excellent communication skills, collaborative mindset

POSITION: Full-Time, Exempt

 

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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