Generation Bio is innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases. The company is developing two distinct and complementary platforms: a potent, highly selective cell-targeted lipid nanoparticle (ctLNP) delivery system and a novel immune-quiet DNA (iqDNA) cargo produced by a scalable capsid-free manufacturing process that uses proprietary cell-free rapid enzymatic synthesis (RES). With these platforms, Generation Bio aims to develop the next wave of non-viral genetic medicines to support its mission to extend the reach of genetic medicine to more people living with more diseases, around the world.  

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.  

Delve further.  Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/ 

SUMMARY:

Generation Bio is seeking a highly motivated and enthusiastic scientist to join our Platform Assays and Analytics team. This role is for a bioanalytical scientist with extensive expertise in gene therapy and nucleic acid therapeutics. The candidate will have hands-on experience measuring the biodistribution and PK of a variety of nucleic acid modalities. In addition, this individual will have demonstrated assay development experience and a diverse background in bioanalytical techniques, e.g. (RT)-qPCR, digital PCR, NGS, cell-based assays, LC-MS, ELISA, flow cytometry.

Primary job responsibilities include: 1) Leading a small team to support platform and preclinical development programs with bioanalytical data 2) Developing assays to address platform-specific questions. 3) Collaborating with cross-functional teams. 4) Mentoring and guiding the career development of direct reports.

This is a significant learning opportunity, and the candidate is expected to be an independent thinker, a self-starter, and someone who is not afraid to push the boundaries of science. The job responsibilities may also include management of CRO relationships (assay transfer, scientific oversight, and ensuring execution in collaboration with our Operations team). Significant cross functional interactions are required.

 

RESPONSIBILITIES:

  • Design, optimize, and execute assays to evaluate various gene therapy parameters; both in vitro and in vivo
  • Lead a small team of bioanalytical scientists to support the bioanalytical needs of the organization
  • Support matrixed teams with functional expertise
  • Employ cutting edge technologies to understand key platform questions
  • Summarize studies in written reports and oral presentations

REQUIREMENTS:

  • PhD with a minimum of 3 years of experience, Masters with a minimum of 8 years of experience, bachelor’s degree with a minimum of 10 years of experience in Bioanalysis or Molecular and/or Cell Biology, or related discipline
  • Biotech and/or pharmaceutical industry experience is preferred
  • Expert in developing biodistribution and PK data for gene therapies; Proficient in developing bioanalytical assays to support gene therapies; Excellent lab-based skills and the ability to work independently to analyze, interpret, and present data
  • Experience managing and/or directing a small team
  • Ability to multi-task to support multiple projects across platform and work in a matrixed environment
  • Organized, excellent communication skills, collaborative, team player mindset

POSITION: Full-Time, Exempt

 

 

 

 

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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