Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases. The company’s non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA. The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient. RES has the potential to expand Generation Bio’s manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.
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SUMMARY:
Generation Bio is seeking a motivated and highly skilled individual to lead platform development of gene editing technologies. This is a director-level position, that reports to the VP, Head of molecular biology. This is a pivotal position within our organization, responsible for leading scientific strategy and technical planning for development of editing technologies. The successful individual will have demonstrated technical expertise and advanced molecular understanding of gene editing technologies broadly, including nuclease and recombinase systems. The candidate will have a track record of building teams and managing cross functional projects successfully. Success in this role includes working cross functionally to integrate development of editing cargo with ctLNP technology for delivery to target tissue. Additionally, the position affords the opportunity for broader impact on cargo engineering efforts across generation Bio including development of iqDNA for episomal and insertional gain of function applications.
RESPONSIBILITIES:
- Build and lead team to develop editing technologies for therapeutic application
- Spearhead and lead design approaches for development of editing technologies
- Accountable for on-time execution of experimental projects to advance our editing platform
- Provide scientific input to influence and shape company objectives and strategy
- Work cross functionally to execute on project objectives, integrate results across project teams and coordinate resources to maximize synergy
- Access and synthesize different sources of information (papers, patents, consultants) to set scientific strategy for meeting platform technology goals
QUALIFICATIONS:
- PhD in Molecular Biology, Synthetic biology, Bioengineering, Biochemistry or related discipline
- Minimum of 10 years of relevant experience, 3 years specifically working on gene editing applications
- Experience engineering/ optimizing editing systems for improved performance and function
- In-depth mechanistic understanding of diverse gene editing technologies (including gene correction and replacement) and their therapeutic application.
- Understanding of DNA repair systems important for driving specific editing outcomes
- Deep understanding of emerging editing strategies including large gene insertion and/or engineered recombinases a plus
- Capacity for strong strategic thinking and critical problem solving
- Proven leadership experience with record of building and developing high performance teams.
- Excellent communication and interpersonal skills with capacity to work internally and externally to forward company goals.
POSITION: Full-Time, Exempt
EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.