Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases. The company’s non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA. The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient. RES has the potential to expand Generation Bio’s manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.  

Delve further.  Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/ 

SUMMARY:

Generation Bio is seeking an energetic and highly motivated molecular biologist with broad expertise in utilizing CRISPR/Cas systems for therapeutic applications. The ideal candidate will have experience developing and executing assays to characterize on- and off-target editing profiles. This role is very cross functional with key interactions between bioinformatics, cell biology, translational biology & formulation teams.

RESPONSIBILITIES: 

  • Develop, optimize, and execute assays to characterize off-target editing events (biased and unbiased)
  • Support on-target editing analysis workflow
  • Assist development of technical strategy in collaboration with broader team
  • Work independently with guidance and support from manager and broader molecular biology team
  • Work with cross-functional teammates including translational biology, cell biology, and bioinformatics

QUALIFICATIONS:

  • Bachelors or Master of Science in Molecular Biology, Biochemistry, Microbiology or related field
  • A minimum of 2 years of industry experience in a relevant field is preferred
  • Hands-on experience with experimental off-target editing analysis methods (e.g., GUIDE-seq, SITE-seq, digenome-seq, etc.)
  • Hands-on experience with experimental on-target editing analysis methods (e.g., Sanger sequencing, NGS)
  • Experience with automated liquid handling systems is a plus
  • Expertise with mammalian cell culture is a plus, especially primary cells (e.g. HSCs)
  • Experience and knowledge of multiple gene-editing systems
  • Fluency and extensive hands-on experience with molecular biology and synthetic biology techniques with a focus on application to mammalian systems

POSITION: Full-Time, Exempt

 

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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