Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases. The company’s non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA. The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient. RES has the potential to expand Generation Bio’s manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.

We are a thriving, collaborative, creative community of 165 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.  

Delve further.  Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/ 

SUMMARY: 

Generation Bio is seeking a highly motivated, enthusiastic, and creative Scientist to join our delivery team.   The primary responsibilities for this position will include the conceptualization, design, and synthesis of lipid nanoparticle formulations.  In this role, the successful individual will integrate knowledge of biology, chemistry, and materials science to develop non-viral vector-based gene therapies.  The successful individual will apply and expand a suite of analytical techniques to the characterization of formulations.  In addition, the successful individual will work in cross-functional teams that include scientists in the Preclinical, Process Science, and Molecular Biology departments.  Joining the Core Delivery Research team in this role is an ideal opportunity to make a significant impact on the advancement of gene therapies.

 

RESPONSIBILITIES:

  • Design and optimize novel formulations based on understanding current critical technical and pharmacological barriers
  • Synthesize novel nanoparticle formulations for multiple delivery routes    
  • Characterize nanoparticle formulations using various physicochemical and in vitro characterization techniques
  • Work closely with preclinical and molecular biology scientists at Generation Bio to evaluate the formulations in cell-based and in vivo models
  • Plan and execute experiments independently
  • Analyze data and present to internal stakeholders
  • Prepare characterization reports and document work in electronic lab notebooks (ELNs).

 

QUALIFICATIONS:

  • Senior Associate Scientist: Bachelor’s degree in biomedical engineering, chemical engineering, chemistry, materials science, or related field with a minimum of 3 years of industry experience in research or development or a Masters degree.
  • Principal Associate Scientist: Bachelor’s degree in biomedical engineering, chemical engineering, chemistry, materials science, or related field with a minimum of 6 years of industry experience in research or development or a Masters degree with a minimum of 3 years of industry experience in research or development
  • Knowledge or experience in lipid nanoparticles or nucleic acid delivery is a plus.
  • Courageous and forward thinking
  • Results-driven with excellent attention to details
  • Experience working in cross-functional teams
  • Ability to prioritize and balance multiple projects
  • Strong communication, interpersonal, and organizational skills.

 

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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