About the Company
Gemini Therapeutics is a biotechnology company pioneering precision therapeutics for patients with high-risk genetic profiles linked to dry age-related macular degeneration (AMD) and rare systemic diseases. Gemini’s therapeutic candidates are matched to molecular abnormalities found in patients with high clinical need, and our broad multimodal pipeline includes monoclonal antibodies, recombinant proteins, and gene therapies. Launched with funding from leading life science investors and powered by academic partnerships around the world, Gemini is developing a series of first-in-class therapeutics. The company currently has 30 employees, and more information is available at www.geminitherapeutics.com.
About the Role:
Associate Scientist/Senior Associate Scientist, Gene Therapy (Vector Operations)
We are currently recruiting a highly motivated and independent Associate Scientist/Senior Associate Scientist to join our Gene Therapy team and oversee preparation, characterization, and qualification of AAV vectors for preclinical studies. Responsibilities will include managing plasmid and AAV vector production at CMOs, establishing and coordinating execution of internal analytics for qualification of purified vector, and ensuring vector availability for scheduled in vivo studies at CROs. The ideal candidate will have experience with AAV molecular and analytical techniques in an industry setting. The successful applicant will collaborate with Gemini scientists and CMOs to streamline vector production, characterization, and qualification. This position will have high visibility, engaging in multiple projects across the organization.
- Manage external vendors for plasmid and AAV production
- Coordinate and assist with downstream vector characterization including qPCR-based titer determination, genome integrity assay, endotoxin assay, and residual DNA/protein assays
- Communicate efficiently with Gene Therapy scientists and CROs to ensure supply of qualified AAV vectors for all scheduled preclinical studies
- Assist with construction and verification of AAV cassettes for transgene expression
- Manage inventory of all plasmids, AAV vectors, and treated tissue samples
- Prepare data summaries/study reports and present internally to colleagues
- Develop and follow protocols, diligently documenting experimental data in electronic lab notebooks and managing material documentation for regulatory filings.
- Actively support a culture of innovation, learning, respect, and trust
- M.S., B.S., or equivalent, in the life sciences with preferably > 5 years industry experience.
- Extensive experience with standard biochemistry and cell/molecular biology assays of gene expression, e.g., western blotting, ELISA, qRT-PCR, and/or IHC/ ISH).
- Hands-on experience with AAV vector preparation, molecular cloning, and activity assays in vitro and/or in vivo
- Basic understanding of retinal disease is a plus
- Ability to independently design, execute, and analyze results of in vitro molecular biology experiments
- Strong communication skills and ability to work effectively on cross-functional teams
- Experience supporting a multidisciplinary project team, including generating high-quality data in a time-sensitive environment, assimilating new information from multiple sources, and effectively communicating with internal and external scientists
- Creative, self-motivated, and able to work independently on data analysis, troubleshooting, and identifying solutions to complex research challenges