About the Company
Gemini Therapeutics is a biotechnology company pioneering precision therapeutics for patients with high-risk genetic profiles linked to dry age-related macular degeneration (AMD) and rare systemic diseases. Their therapeutic candidates are matched to molecular abnormalities found in patients with high clinical need and Gemini’s broad multimodal pipeline includes monoclonal antibodies, recombinant proteins and gene therapies. Launched with funding from leading life science investors and powered by academic partnerships around the world, Gemini is developing a series of first-in-class therapeutics. The company currently has 30 employees, and more information is available at www.geminitherapeutics.com.
About the Role:
Scientist/Senior Scientist, Gene Therapy (Pharmacology)
We are currently recruiting a highly-motivated and independent Research Sr/Scientist to join our Gene Therapy team. We are looking to expand our research efforts and advance our lead assets into preclinical evaluations. This laboratory-based position will be responsible for the development of in vitro methodology and analysis of in vivo data to aid in the optimization of novel gene therapies for age-related macular degeneration.
The successful applicant will collaborate with Gemini scientists and with our academic partners and CROs to advance the pipeline. This position has tremendous room for growth and opportunities to gain experience across multiple areas of R&D, including gene therapy, pharmacology, and translational biology, both internally and externally.
- Design and execute preclinical studies evaluating in vivo pharmacology of AAV vectors for treatment of retinal disease
- Design, construct, and optimize transgene cassettes for packaging into AAV vectors.
- Evaluate transgene expression in cultured cells and in AAV vector-treated retina samples using standard cell and molecular biology methods
- Work collaboratively with Gemini team members and external partners to generate high-quality data that advance assets in our pipeline.
- Maintain current knowledge of emerging technologies and scientific approaches in the gene therapy space, particularly with regard to AAV vectors
- Prepare summaries of data and present internally to colleagues and management.
- Develop and follow protocols, diligently documenting experimental data in electronic lab notebooks and authoring scientific reports for internal documentation or regulatory submissions.
- Actively support a culture of innovation, learning, respect, and trust
- PhD., or equivalent, in the life sciences with preferably > 2 years of post-doctoral experience.
- Scientific training and background in molecular biology, assay development, and evaluation of gene expression, e.g., western blotting, ELISA, RT-qPCR, IHC, and/or ISH).
- Hands-on experience with AAV vector design, molecular cloning, and evaluating activity in vitro and/or in vivo is preferred.
- Basic understanding of retinal disease is a plus.
- Strong communication skills and ability to work as part of a team.
- Experience supporting a multidisciplinary project team, including generating high-quality data in a time-sensitive environment, assimilating new information from multiple sources, and effectively communicating with internal and external scientists.
- Creative, self-motivated and the ability to work independently including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.