Metaphore Biotechnologies (previously known as Flagship Labs 72 or FL72) is an early-stage biotechnology company building the premier computationally driven bioplatform for the intelligent design of molecular mimicry. Our platform integrates massively parallel assays with machine-learning-guided protein engineering to navigate the combinatorial space of molecular interactions and design protein-protein interfaces with exquisite precision. This capability unlocks best-in-class monoclonal antibodies, next-generation vaccines, and novel therapeutic paradigms across multiple categories of chronic disease.


We are currently located in Kendall Square, Cambridge, in the state-of-the-art facilities of Flagship Labs and will likely move to a larger facility around CambridgeSide.

Metaphore Biotechnologies is a product of Flagship Pioneering’s venture creation engine, which has also given rise to companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), and Editas Medicines (NASDAQ: EDIT). Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.

The opportunity

Metaphore Biotechnologies is seeking highly motivated co-ops to join our growing team for six months starting in July 2023. Internships offer the opportunity to work in a fast-paced startup environment working on cutting-edge biotech techniques. You will have the opportunity to be one of the first 20 members of a highly multidisciplinary the team and work collaboratively with all the core functions as we mature our technology towards the clinic.

Primary responsibilities

  • Perform phage library selections on various targets
  • Evaluate protein binding by ELISA or Biolayer Interferometry
  • Prepare samples for next generation sequencing (NGS)
  • Maintain an electronic lab notebook
  • Work with other teams in a matrix environment
  • Troubleshoot experiments as needed
  • Present results at company meetings


  • 1+ years hands-on lab experience
  • Experience with basic molecular biology and biochemical techniques
  • Strong documentation, communication, and time-management skills to excel in a fast-paced, start-up environment
  • Ability to work independently and as a team member with confidence, self-motivation and scientific curiosity

Experience this opportunity provides you

  • Biotech startup experience
  • 1:1 coaching and mentorship in how to use experiments to answer big questions that advance basic research towards clinical applications
  • An opportunity to learn how data science interfaces with the next frontier of drug hunting and development
  • Collaborations within Metaphore teams from computational therapeutic design to translational studies. We are a small and scientifically-driven team that enjoys learning and working together.

Values and Behaviors:

Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidates.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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