What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?
FL94 Inc., is a privately held, early-stage biotechnology company pioneering Protein Editing. At FL94 we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of novel chemistry modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with machine learning to enable generative design of protein editing chemistries. FL94 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL94 from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
FL94 is seeking an experienced, creative, and talented Principal Scientist or Senior Scientist of Platform Biology to join our research team. You will be part of the team responsible for developing a platform of diverse assays and technologies to invent, create and validate novel chemistry modalities. The ideal candidate brings primary expertise in molecular biology, chemical biology with a proven track record of building high quality and high throughput cell based & biochemical based assay platforms. A background in industrial drug discovery & experience in induced proximity-based modalities, like PROTACs, is preferred.
Successful candidates will be able to thrive in a fast-paced, action-oriented, team environment and display a clear passion for science and impact. The individual will have demonstrated evidence of technical expertise and experience overcoming challenges and moving projects forward with urgency. Experience guiding junior scientists technically and strategically will be important. They will be interested in contributing at the bench and be dedicated to scientific development of themselves and their team.
- Build chemical biology & molecular biology platform to invent, create and validate novel chemistry modalities, including induced proximity technologies, through key proof of concept studies
- Develop & implement a high throughput platform for the characterization of induced protein interactions using diverse chemical and molecular biology techniques such as unnatural amino acid encoding, site-directed mutagenesis, and activity-based protein profiling
- Drive biology experiments to assess targets, biochemically evaluate candidate small molecules, and support drug discovery of several high value, unprecedented targets
- Manage outsourced biochemistry and cell biology resources, establishing and maintaining excellent working relationships with CROs and academic collaborators
- Work collaboratively in cross-functional chemistry, proteomics, drug discovery and AI/machine learning teams
- Ensure rapid and accurate turnaround of data, to agreed timelines, to drive achievement of key project goals
- Translate experimental data into meaningful insights, and present the analyzed data in team meetings
- Ph.D. in Chemical Biology, Biochemistry, Molecular Biology or equivalent
- 5-8+ years of academic and/or industrial drug discovery experience, with a track record of high-quality project deliveries and technical innovation
- Expertise in modern molecular biology techniques including the development of methods to site-specifically incorporate unnatural amino acids into proteins is required
- Experience working with induced proximity technologies, such as PROTACs and molecular glues, is a plus.
- Passion for and experience working with therapeutic companies committed to integration of AI / Data Science across all layers of the business is a plus
- Sound knowledge of other disciplines involved in drug discovery (biophysical methods, NGS, HT screening, LC-MS)
- Demonstrated ability to work within highly skilled teams in a fast-paced, quickly evolving technical environment
- Excellent communication and presentation skills, capable of conveying scientific information in a concise and effective manner.
Location: Cambridge, MA
More About Flagship Pioneering
Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $100 billion in aggregate value. To date, Flagship has deployed over $3.1 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises transformative companies, including Moderna (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Seres Therapeutics (NASDAQ: MCRB), Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Generate Biomedicines, Tessera Tx, and others.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.