Company Summary:

What if…you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Apriori Bio is an early-stage biotechnology company with an ambitious and exciting mission: to lay the foundation for Global Pathogen Shield protective interventions that that can neutralize a wide range of the most dangerous and rapidly evolving infectious pathogen threats.  The company is developing a revolutionary approach to this challenge and recruiting a team of top-tier scientists to build what it believes will be a powerful, first-in-category R&D platform.

Apriori Bio is a product of Flagship Pioneering’s venture creation engine, which has also given rise to companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), and Editas Medicines (NASDAQ: EDIT). Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

We are seeking a highly motivated, collaborative, and detail-oriented Senior Scientist to join our growing team to develop the next generation of vaccines and antibody therapeutics for infectious disease. This is an excellent opportunity for a skilled molecular biologist to build additional skills in library-scale molecular biology, cutting-edge high throughput screening methods, and next generation sequencing. The role requires a strong background in molecular biology, attention to detail and organization, and comfort working in a fast-paced entrepreneurial environment. Experience with protein engineering, deep mutational scanning, or other functional genomics approaches is a plus. This individual will be an integral part of a highly collaborative and interdisciplinary team at the interface of virology, functional genomics, and vaccine design. This candidate should be comfortable in a fast-paced and collaborative start-up environment.

Key Responsibilities:

  • Establish robust, scalable workflows to design, clone, and characterize large scale DNA libraries.
  • Collaborate with a larger team of scientists to leverage high throughput screening platforms (yeast/mammalian cell/viral display, etc.) to interrogate antigenicity and viral fitness at massive scale.
  • Ensure library design, screening strategies, and analyses are tightly linked to protein structure/function and aligned with project goals.
  • Collaborate with computational scientists to guide data analysis, interpret results, and build a rapid iterative experimental cycle.
  • Analyze data promptly to clearly depict and communicate results to the cross-functional team and to leadership.

Basic Qualifications:

  • Ph.D. with 5+ years of experience molecular biology, synthetic biology, genomics, bioengineering, or a related field
  • Strong hands-on experience in molecular biology, including PCR, primer design, cloning, sequencing, sequence analysis, etc.
  • Working knowledge of protein structure/function relationships
  • Knowledge of modern cloning approaches (e.g. Gibson, GoldenGate, etc.)
  • Experience with next generation sequencing (Illumina, long-read, etc.)
  • Stellar work ethic and a passion for benchwork 
  • Strong organizational and record-keeping skills
  • Effective and proactive communication

Preferred Qualifications:

  • Expertise in generating diverse DNA libraries, high-throughput cloning, and/or NGS
  • Experience in high-throughput screening, functional genomics, and/or protein engineering
  • Experience with antibody characterization, immunological assays, viral entry proteins, and/or cell-based functional assays
  • Experience with automation or liquid handlers 

 Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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