Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

Tessera Therapeutics is seeking a highly motivated bioanalytical scientist with a strong background in molecular biology and biochemistry to fulfill a Scientist role in our DMPK group. The candidate will be responsible for developing and employing DMPK assays to characterize and quantitate RNAs to support research, non-clinical, and clinical development programs for a variety of therapeutic indications. The ideal candidate must have excellent new assay development skills and is willing to work in a highly dynamic and fast-paced work environment.

Key Responsibilities:

  • Develop RT-qPCR, branched DNA and other molecular biology or biochemical assays for characterization and quantitation of RNA in various biological matrices including biofluids, tissues, cells, and subcellular fractions.
  • Design and execute experiments from sample preparation, RT-qPCR, and other assays to data analysis & interpretation.
  • Coordinate method transfer to CRO and serve as technical expert for method trouble shooting.
  • Write method protocols, sample analysis procedures. Prepare bioanalytical study reports and data presentations.
  • Contribute to study reports to be submitted to regulatory agency for drug candidate advancement.

Basic Qualifications:

  • PhD or MS degree in Biochemistry, Molecular Biology, or related disciplines, e.g., Biotechnology or Pharmaceutical Science, with 0-3 (PhD) or 7+ years (MS) post-graduate experience. Industrial (biotech, pharmaceutical, and/or CROs) experience is preferred.
  • Experience in assay development and troubleshooting is required.
  • Hands-on experience in RNA extraction from in vivo samples such as plasma or tissue is essential.
  • In-depth scientific knowledge and hands on technical expertise in molecular biology assays, biochemical assays are required.
  • Previous experience in LC-MS bioanalysis is preferred, but not required.
  • Excellent organizational and communication skills.
  • Ability to conduct multiple laboratory and project tasks efficiently.
  • Ability to work in a team-oriented environment with flexibility.

More About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.


Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.


Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
+ Add Another Employment