Company Summary: 

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first re-dosable and targetable genetic medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.

Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

Ring Therapeutics is seeking an in vitro biology Director or Senior Director to join the Platform and Biology team to help develop new Anellovector therapeutics.  This is a senior role involving scientific leadership and coordination of research activities in a complex multidisciplinary organization.  The successful candidate will participate in the conceptualization, characterization, and optimization of engineered therapeutic proteins and their vectors.  The candidate will oversee and participate in the design and execution of in vitro cell biology experiments, including data analysis and communication.  The candidate will collaborate regularly with teams carrying out payload/protein engineering, vector engineering, and in vivo biology.  The successful candidate may also interface with external parties such as vendors, academic research teams, and contract research organizations as required to accelerate the development effort. This will be a great opportunity to make an impact in the development of cutting-edge gene therapy products. We are searching for enthusiastic and highly motivated individuals who are comfortable multitasking and working both with a team and independently on various aspects of the viral platform development.

Key Responsibilities:

  • Conceptualize, oversee, and participate in the development and use of cell-based assays to characterize new viral vectors and therapeutic payloads/proteins in vitro
  • Study molecular and cell biology relevant to Ring’s Anellovectors
  • Supervise researchers delivering on key research objectives
  • Ensure compliance with safety, scientific data documentation
  • Communicate results to multiple Ring Therapeutics stakeholders

Qualifications:

  • Ph.D. in cell and molecular biology, or closely related field
  • 10-15 years of experience in pharmaceutical or biotechnology industry settings
  • Experience with
    • gene therapy discovery and development
    • differentiated primary cell culture systems, 2D or 3D organoids, iPSC, or organ-on-a-chip technology, etc, is required
    • assay development, especially using primary cells or explant tissue culture, is required
    • advanced microscopy imaging techniques (confocal, multi-photon, etc) is required
    • molecular biology and recombinant DNA techniques
  • Demonstrated ability to work with highly skilled multidisciplinary teams in a fast-paced, entrepreneurial, and technical environment
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
  • Comfortable delivering against challenging commitments
  • Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment
 
 
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
 
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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