Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first re-dosable and targetable DNA medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.
Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), and Indigo Agriculture.
Ring Therapeutics is seeking an in vitro biology Scientist or Senior Scientist to join the Platform and Biology team to help develop new Anellovector therapeutics. The candidate will help design, characterize, and optimize engineered therapeutic proteins and their vectors. The candidate will design and perform in vitro cell biology experiments, as well as analyze, and present data. The candidate will work with teams carrying out protein engineering, vector engineering, and in vivo biology. The successful candidate may also interface with external parties such as vendors, academic research teams, and contract research organizations as required to accelerate the development effort. This will be a great opportunity to participate in the development of cutting-edge gene therapy products. We are searching for enthusiastic and highly motivated individuals who are comfortable multitasking and working both with a team and independently on various aspects of the viral platform development.
- Develop and use cell-based assays to characterize new viral vectors and therapeutic proteins in vitro
- Study molecular and cell biology relevant to Ring’s Anellovectors
- Supervise research associates supporting key research objectives
- Maintain lab notebooks, and report results to the scientific team
- Ph.D. in cell and molecular biology, or closely related field
- 2-5 years of postdoctoral experience, in academic, pharmaceutical, or biotechnology settings. Industry experience preferred.
- Experience with
- differentiated primary cell culture systems, 2D or 3D organoids, iPSC, or organ-on-a-chip technology, etc, is required
- assay development, especially using primary cells or explant tissue culture, is required
- advanced microscopy imaging techniques (confocal, multi-photon, etc) would be a plus
- molecular biology and recombinant DNA techniques
- use of viral vectors for gene delivery and therapy
- Demonstrated ability to work with highly skilled teams in a fast-paced, entrepreneurial, and technical environment.
- Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
- Comfortable delivering against challenging commitments.
- Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment.