Company Summary:

Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of dynamic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and products that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. The current Flagship ecosystem comprises 41 transformative companies, including: Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS). 

Position Summary:

Generate Biomedicines is looking for an individual to be a part of a growing protein sciences department that is leveraging automated high-throughput platforms in multiple areas of protein production and characterization workflows. The individual will contribute to workflows that include protein expression, purification, and characterization of proteins in high throughput platforms.  They will work collaboratively with the Protein Science team in delivering purified and characterized proteins that help support multiple programs and platforms across the company. This position will focus on the production of recombinant proteins across a range of protein modalities and characterizing these proteins for properties such as size, purity and aggregation.  They will be responsible for designing experiments and analyzing data with the help of their supervisor. This is an exciting opportunity to be part of a fast-paced, start-up environment.

Responsibilities may include, but are not limited to:

  • Execution of high-throughput automated protein expression and purification workflows using liquid handling robots.
  • Running and developing methods for AKTA based purifications.
  • Assessing protein quality through analytical techniques (SDS-PAGE, Western Blot, Analytical Size Exclusion).
  • Detailed documentation of experiments and data on our internal LIMS systems and electronic notebook.
  • Excellent attention to detail, documentation, and communication skills.
  • Outstanding team player with a focus on collaboration.

Preferred skills:

  • Operation of liquid handling robots.
  • Proficiency working with multiple expression systems (mammalian, insect and E. coli).
  • Familiar with various affinity purifications (His, Protein A, Strep).
  • Ability to program and run AKTA systems.
  • Experience with SDS-PAGE, iBlot, Agilent HPLC and LabChip.

Minimum Education Experience: B.S degree 

Minimum Industry Experience: 1-3 years experience in Biotech or Pharma industry

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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