What if…you could join an organization that creates, resources and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Company Summary:

Flagship Labs 75, Inc. (FL75) is a privately held, early-stage biotechnology company that is pioneering the development of multi-specific medicines to deliberately and systematically drug complex biology. FL75 is a highly dynamic, entrepreneurial and innovation-driven organization seeking to hire an exceptional computational scientist to join our team.

FL75 was founded in Flagship’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

Flagship Labs 75, Inc is looking for a highly motivated and enthusiastic Research Associate to join our Protein Sciences team. This individual will be part of the team responsible for the design and engineering of therapeutic proteins and multi-specific protein reagents such as bispecific antibodies. This is an exciting opportunity to contribute to the development of the next generation of biologics in a dynamic and entrepreneurial environment.

Key Responsibilities

  • Contribute to the design and production of engineered proteins, monoclonal/bispecific antibodies and other biologics molecules of interest to the company.
  • Clone/generate plasmid DNA constructs for expression of therapeutic and other proteins.
  • Perform biochemical and biophysical assessments of expressed proteins.
  • Collaborate with the in vivo and biological sciences teams to investigate new candidate molecules.
  • Present results, conclusions and next steps clearly and succinctly to the team.
  • Contribute to patent filings.
  • Maintain clear, accurate written records of laboratory procedures, results and conclusions.

Desired Qualifications and Capabilities

  • BS/MS in biochemistry, molecular or structural biology, or related disciplines.
  • At least two years of hands-on experience working in academic or biotech settings with protein structure/function, protein engineering and optimizing protein expression, purification and characterization.
  • Experience with the following:
    • Gene design, vector construction, and protein expression.
    • SDS-PAGE, HPLC, ELISA, Octet, SPR, flow cytometry/FACS
    • Cell culture and large-scale transient transfections for protein expression.
    • Protein purification techniques using a variety of methods.
  • Strong communication skills, both written and verbal, to clearly convey results and scientific data to senior leaders, teams, academic collaborators and partners.
  • Highly motivated strong team player who enjoys working in a fast-paced, inclusive, ethical, team-oriented, multidisciplinary environment of a small biotech.

Preferred Qualifications:

  • Engineering of bispecific and other non-traditional protein formats
  • Experience using a mass spectrometry device of analyzing mass. Spec data
  • Experience with structural modeling, epitope mapping, protein structure-function relationships


Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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