Company Summary:

Tessera Therapeutics is pioneering Gene Writing™—a new genome engineering technology that writes therapeutic messages into the genome to treat diseases at their source. Tessera Therapeutics was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ: MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health (AXLA), Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

Tessera Therapeutics is seeking a motivated and creative Scientist to join a team of scientists and engineers focused on the process development of mRNA production.  This will include, but not limited to, high-throughput mRNA production process development and automation, process scale-up, process execution to make material for preclinical studies. This individual will join a dynamic, rapidly growing, and highly collaborative team that is driving the mRNA process development for a novel platform of Gene Writing.

Key Responsibilities:

  • Lead the development of in-house high-throughput mRNA production capabilities, with an emphasis on automation, establishing a scalable/transferable process for producing high-purity material.
  • Design and lead experimental plans for screening, and optimization of a high-throughput platform using liquid handling systems like Tecan/ Hamilton.
  • Lead development of reliable scale down models using complex DoEs in a high throughput set up to optimize RNA synthesis and purification.
  • Assist with data management, lead analysis of complex DoE data and contribute to advance Tessera’s RNA platform with end-to-end process integration.
  • Troubleshoot lab workflows and maintain equipment.
  • Provide high quality results and documentation in electronic lab notebooks.
  • Write protocols and technical reports to support drug substance and drug product clinical development.
  • Collaborate effectively with formulation and analytical development teams.

Basic Qualifications:

  • PhD, or BS/MS with 3+ years of relevant industrial experience. A degree in either Chemical Engineering, Bioengineering, or Biological Sciences.
  • Hands on experience with liquid handling systems like Tecan/ Hamilton is required.
  • Experience with automation, process integration, data management is required.
  • Experience with programming (C/ Matlab) for process development is preferred.
  • Technical understanding and experience in biopharmaceutical process development including protein/ mRNA synthesis, purification using robocolumns is preferred.
  • Understanding of nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for macromolecules is preferred.
  • Hands on experience with in vitro transcription and mRNA purification technologies is a plus.
  • Experience with analysis of DNA sequencing data is preferred.
  • Track record of completing deliverables within specified timelines.
  • Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial, and technical setting.
  • The successful candidate should be collaborative, communicative, and passionate about working with RNA molecules leading to mediate the next generation of genetic medicines.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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