Company Summary:

Flagship Labs 68, Inc. is a well-funded, early-stage biotechnology company founded by Flagship Pioneering that is primed to revolutionize cell therapeutics. Since early 2020, FL68 scientists have been characterizing a novel, but overlooked, cell behavior and built the foundation for exploiting this behavior for an entirely new type of cellular therapeutic. FL68 is currently hiring for several roles to rapidly expand on this early work and to pursue a multi-modality platform with the potential to generate cures across a diverse landscape of diseases. In the next 1-2 years, the company seeks to reduce this therapeutic model to practice, demonstrate usefulness across a range of applications, and complete pre-clinical proof-of-concept studies. We are seeking highly motivated and uniquely creative scientists to push our science to the next level and create truly novel medicines.

FL68 was founded in Flagship’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), and Editas Medicines (NASDAQ: EDIT) were conceived and created.  Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

FL68 is seeking an innovative and highly motivated Senior or Principal Scientist to assemble our in-house cell engineering strategies and validate novel target discovery approaches. The ideal candidate will have deep knowledge in cell biology and full command of rapid molecular cloning techniques and CRISPR-based human genome engineering. This individual will drive parallel cell prototyping efforts to modify and optimize cells for use in our entirely unique cell therapy approach. This role will also include some management responsibilities and will provide input into broader company strategy. The candidate will bring an entrepreneurial spirit, be independent, goal oriented, demonstrate strong communication skills, and be comfortable to collaborate and contribute to a very dynamic and cross-functional team environment.

Key Responsibilities:

  • Conceive of strategies for achieving a set of specific cell characteristics
  • Design and implement CRISPR-based genome editing in human cells
  • Implement non-viral gene delivery methods in vitro, including transposon anc CRISPR-based genome engineering
  • Systematically validate and optimize each cell modification for in vitro and in vivo
  • Manage and mentor junior scientists and research associates
  • Analyze, interpret, and organize data to prepare experimental reports and communicate the results of the projects at internal and external meetings
  • Collaborate with teams to facilitate discovery for preclinical proof-of-concept and IND-enabling studies
  • Manage experiments conducted through CROs
  • Proactively review literature to contribute to new ideas and technologies

Key Requirements:

  • Ph.D. in biological related field with at least 2 years postdoctoral or biotech experience in genome engineering
  • Extensive experience with CRISPR engineering (such as targeted KI, multiplexed gene editing, or base editing) and molecular cloning
  • Experience with the design and functional assessment of modifications of CRISPR/Cas9 gRNAs
  • Strong experimental skills with DNA and RNA biology techniques including PCR, qPCR, western blot, Immunofluorescence microscopy, plasmid, RNA, primer and gRNA designs
  • Experienced with primary human cell culture, cell-based biological assay development, and cell phenotype analysis
  • Familiarity with diverse immunology and cell biology techniques, including flow cytometry, cell culture, cell function assays, and imaging techniques
  • Experience with transposon and siRNA systems is a plus
  • Experience in building and implementing CRISPR-based libraries for high-throughput screens is a plus
  • Designing and managing mouse studies to validate desired cell behaviors in vivo is a plus
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
  • Team oriented, execution focused with strong work ethic, and highly motivated to develop a transformative therapeutic discovery and target validation platform
  • Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals, patents, and conference proceedings

 

More About Flagship Pioneering

We are creative optimists and we would love for you to consider joining our team!  See all our open opportunities across Flagship Pioneering’s Ecosystem!

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. To date, Flagship is backed by more than $4.4 billion of aggregate capital commitments, of which over $1.9 billion has been deployed toward the founding and growth of its pioneering companies alongside more than $10 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including:  Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO),  Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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